Type of antibody:
Primary antibodies, Recombinant antibodies
recombinant human IgG1
Alternative names:
PRO940, SLG2, Siglec10, Siglec-like protein 2 (SLG2)

Specifications for Siglec-10 Antibody, anti-human, REAfinity™


Clone REA1048 recognizes the human siglec-10 antigen, also known as sialic acid-binding Ig-like lectin 10, which is a member of the CD33-related group of siglecs. The cytoplasmic tail of siglec-10 contains four tyrosines, two of which are embedded in ITIM-signaling motifs and are likely to be involved in intracellular signaling. Amongst peripheral blood leucocytes, siglec-10 was found to be expressed on eosinophils, monocytes, and B cells. Higher levels of siglec-10 were found on a minor subset of NK-like cells that express the CD16 low-affinity Fc receptor but lack the CD56 antigen. The molecular properties and expression pattern suggest that siglec-10 may have evolved to function as an inhibitory receptor of the innate immune system.
Additional information: Clone REA1048 displays negligible binding to Fc receptors.

Alternative names

PRO940, SLG2, Siglec10, Siglec-like protein 2 (SLG2)

Detailed product information

Technical specifications

Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hosthuman cell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Alternative names of antigenPRO940, SLG2, Siglec10, Siglec-like protein 2 (SLG2)
Molecular mass of antigen [kDa]75
Distribution of antigenB cells, monocytes, eosinophils
Entrez Gene ID89790
RRIDAB_2733712, AB_2733713, AB_2733299, AB_2733300, AB_2732929, AB_2732930

Resources for Siglec-10 Antibody, anti-human, REAfinity™


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References for Siglec-10 Antibody, anti-human, REAfinity™


  1. Munday, J. et al. (2001) Identification, characterization, and leucocyte expression of siglec-10, a novel human sialic acid-binding receptor. Biochem. J. 355: 489-497
  2. Kitzig, F. et al. (2002) Cloning of two new splice variants of Siglec-10 and mapping of the interaction between Siglec-10 and SHP-1. Biochem. Biophys. Res. Commun. 296(2): 355-362
  3. Bandala-Sanchez, E. et al. (2013) T cell regulation mediated by interaction of soluble CD52 with the inhibitory receptor Siglec-10. Nat Immunol 14(7): 741-748

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