A new dimension in neuroscience research

Imagine you had the possibility of visualizing the entire complex cellular network of an intact, whole brain at high resolution, in 3D, without sectioning. 

Wouldn’t this open up a whole new world in your neuroscience research? And this is exactly what you can do using UltraMicroscope light sheet imaging systems in combination with tissue clearing – no matter whether you study neuronal connectivity and regeneration, neurodegenerative diseases, such as Alzheimer’s and Parkinson’s diseases, or brain injury and stroke. The UltraMicroscope Blaze™ is specially designed to image entire biological systems, like whole rodent brains or even an entire mouse body, at high resolution to perfectly address the needs of neuroscientists.  

Full automation of the instrument and our optimized, ready-to-use clearing and labeling reagents make this groundbreaking technology a walk in the park – even if you’re just about to start your 3D neuroimaging project. It has never been so easy to add a new dimension to your research. 

Neuroscience research in action

Video

Paper of the month by Robin Vigouroux, Ph.D.

Institut de la vision, Sorbonne Université, Paris, France

Robin Vigouroux speaks on his project investigating the evolution of 3D vision. A sophisticated tissue clearing method (EyeDISCO) allowed him and his coauthors to image whole bilateral visual projections from the eye to the brain by 3D light sheet microscopy in various species. 

To understand the nervous system’s architecture and function, we require comprehensive 3D data. 
The UltraMicroscope Blaze provides us that in spades,  
and the new insights we gain from these 3D images definitely change the way we see the brain. 
Dr. Alain Chédotal
Sorbonne Université, INSERM, CNRS, Institut de la Vision, Paris, France
Reference list

Success stories written by UltraMicroscope users

Scientists from across the globe continuously make stunning discoveries with the help of UltraMicroscope light sheet systems. Take a look at this list of selected publications to find out more about the wide range of innovative neuroscience applications that rely on UltraMicroscope technology.

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Video

Dr. Ali Ertürk speaking on Neuroscience

In this interview Dr. Ali Ertürk, Director of iTERM, Helmholtz Zentrum München, Germany shows how the new light sheet microscope UltraMicroscope Blaze enabled him to visualize a whole cleared mouse brain in 3D to analyze the complete vasculature in detail – from the carotid arteries through to small capillaries in the cortex.

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