Clone REAL956 is an antibody fragment derived from the full Somatostatin antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL956 recognizes Somatostatin, also known as SIH (somatotropin (release)-inhibiting hormone) or GHIH (growth hormone (release)-inhibiting hormone)) or by several other names. Somatostatin is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation. Somatostatin inhibits the secretion of several hormones, including growth hormone, thyroid stimulating hormone, cholecystokinin, insulin and glucogon. It also inhibits the activity of the gastrointestinal tract and the rapid reproduction of normal and tumour cells. Somatostatin may also act as a neurotransmitter in the nervous system.
Synthetic analogs of Somatostatin are used for the treatment of a variety of disorders including acromegaly and the symptomatic treatment of carcinoid tumors and vasoactive intestinal peptide tumors.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).
