CD8a Antibody, anti-human, REAfinity™
Clone:
REA1024
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
MICS, IF, IHC
Alternative names:
Leu-2, CD8a, MAL, p32, Cd8b1, LY3, Lyt3, P37, Ly-2

Specifications for CD8a Antibody, anti-human, REAfinity™

Overview

Clone REA1024 recognizes the human CD8 antigen, a cell-surface glycoprotein, also known as Leu-2 or CD8a. CD8 is strongly expressed on human cytotoxic T cells and thymocytes, and on a subset of NK cells. The CD8 antigen is a disulfide-linked dimer that exists either as a CD8a homodimer or as a CD8α/β heterodimer. CD8 acts as a coreceptor for the T cell receptor and binds to the MHC Class I molecules. CD8 is involved in T cell development and activation of mature T cells. The CD8 antibody recognizes the α-subunit of the antigen.
Additional information: Clone REA1024 displays negligible binding to Fc receptor.

Alternative names

Leu-2, CD8a, MAL, p32, Cd8b1, LY3, Lyt3, P37, Ly-2

Detailed product information

Technical specifications

CloneREA1024
Clonalitymonoclonal
Isotyperecombinant human IgG1
Hosthuman cell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD8a
Alternative names of antigenLeu-2, CD8a, MAL, p32, Cd8b1, LY3, Lyt3, P37, Ly-2
Molecular mass of antigen [kDa]24
Distribution of antigenNK cells, T cells, thymocytes
Entrez Gene ID925
RRIDAB_2857415, AB_2857416, AB_2857414

Resources for CD8a Antibody, anti-human, REAfinity™

Certificates

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References for CD8a Antibody, anti-human, REAfinity™

Publications

  1. Devine, L. et al. (1999) Orientation of the Ig domains of CD8 alpha beta relative to MHC class I. J Immunol 162(2): 846-851
  2. Gao, G. F. et al. (2000) Molecular interactions of coreceptor CD8 and MHC class I: the molecular basis for functional coordination with the T-cell receptor. Immunol. Today 21(12): 630-636

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