Clone REA1307 recognizes the human CD4 antigen, a 55 kDa Single-pass type I membrane protein also known as T4/Leu-3. CD4 is a member of the immunoglobulin superfamily that plays an essential role in the immune response. It is involved in the recognition of MHC class II/peptide complexes by the TCR heterodimers and functions as a co-receptor of the T cell receptor (TCR). CD4 is the receptor for the human immunodeficiency virus (HIV). CD4 is highly expressed on T helper cells and at a lower level on endothelial cells, monocytes, macrophages and dendritic cells.
Additional information: Clone REA1307 displays negligible binding to Fc receptors.
