Type of antibody:
Primary antibodies, Recombinant antibodies
recombinant human IgG1
Alternative names:
IL-7R, IL-7Rα, IL-7Ralpha

Specifications for CD127 Antibody, anti-mouse, REAfinity™


Clone REA680 recognizes the mouse antigen CD127, also known as IL-7 receptor α chain (IL-7Rα). Mouse CD127 is a 60–90 kDa type I transmembrane glycoprotein. It is a component of the high affinity IL-7 receptor (IL-7R) and the receptor for thymic stromal lymphopoietin (TSLP). CD127 is expressed on immature B cells, CD4
, CD4
, and CD8
thymocytes, naive and memory T cells, thymic NK cells, and bone marrow stromal cells. Upon activation of naive T cells, CD127 expression is downregulated. Re-expression of CD127 identifies the effector cells that will differentiate into memory T cells.
Additional information: Clone REA680 displays negligible binding to Fc receptors.

Alternative names

IL-7R, IL-7Rα, IL-7Ralpha

Detailed product information

Technical specifications

Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hosthuman cell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Alternative names of antigenIL-7R, IL-7Rα, IL-7Ralpha
Molecular mass of antigen [kDa]50
Distribution of antigenB cells, T cells, monocytes, lymphocytes, thymocytes, bone marrow, liver
Entrez Gene ID16197
RRIDAB_2783928, AB_2654845, AB_2654846, AB_2751849

Resources for CD127 Antibody, anti-mouse, REAfinity™


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References for CD127 Antibody, anti-mouse, REAfinity™


  1. Colpitts, S. L. et al. (2009)
    IL-7 receptor expression provides the potential for long-term survival of both CD62L
    central memory T cells and Tʜ1 effector cells during
    Leishmania major
    J. Immunol. 182: 5702-5711
  2. Vosshenrich, C. A. et al. (2006) A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127. Nat. Immunol. 7: 1217-1224
  3. Kaech, S. M. et al. (2003) Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat. Immunol. 4: 1191-1198
  4. Sudo, T. et al. (1993) Expression and function of the interleukin 7 receptor in murine lymphocytes. Proc. Natl. Acad. Sci. U.S.A. 90: 9125-9129
  5. Goodwin, R. G. et al. (1990) Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily. Cell 60: 941-951

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