Clone REA320 recognizes the human and mouse Sox2 antigen, a member of the SRY-related HMG-box family of transcription factors. The SRY-containing protein Sox2 is known to regulate the self-renewal of mouse and human embryonic stem cells. It is also important for the maintenance of stem cells in multiple adult tissues including brain and trachea, and it is one of the key transcription factors for establishing induced pluripotent stem cells. Sox2 forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1, and ZFP206. Overexpression and gene amplification of Sox2 have been associated with the development of squamous cell carcinoma in multiple tissues such as the lung and esophagus.
Additional information: Clone REA320 displays negligible binding to Fc receptors.
