Specifications for Plexin-D1 Antibody, anti-human, REAfinity™
Overview
Clone REA542 recognizes the human plexin-D1 antigen, a type I transmembrane glycoprotein that is a member of the D subfamily of semaphorin receptors. Plexin-D1 is amongst others the receptor for semaphorin 3E (Sema3E) which is a secreted molecule implicated in axonal path finding and inhibition of developmental and postischemic angiogenesis. Plexin-D1 plays an important role in cell-cell signaling and in regulating the migration of a wide spectrum of cell types, and is able to trigger R-Ras inactivation, leading to axonal and cell repulsion
in vitro. Moreover, it was shown that Sema3E mediates either axonal attraction or repulsion in distinct neuronal populations, depending on the coexpression of neuropilin-1 with plexin-D1. Plexin-D1 expression is generally low in normal adult tissues, it is elevated in endothelial cells of tumor vessels and in cancer cells.
Additional information: Clone REA542 displays negligible binding to Fc receptors.
Alternative names
PLXND1, PLEXD1Detailed product information
Technical specifications
| Clone | REA542 |
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| Clonality | monoclonal |
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| Isotype | recombinant human IgG1 |
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| Isotype control | REA Control Antibody (S), human IgG1 |
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| Host | human cell line |
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| Type of antibody | Primary antibodies, Recombinant antibodies |
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| Species | human |
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| Antigen | Plexin-D1 |
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| Alternative names of antigen | PLXND1, PLEXD1 |
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| Molecular mass of antigen [kDa] | 208 |
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| Distribution of antigen | endothelial cells |
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| Entrez Gene ID | 23129 |
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| RRID | AB_2889734, AB_2653249, AB_2653250, AB_2653253, AB_2653254, AB_2653255, AB_2653256, AB_2928806, AB_2928805, AB_2889735 |
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