Clone:
REA1319
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
MICS, IF, IHC
Alternative names:
CDH1, Arc-1, CDHE, ECAD, LCAM, UVO, E-Cadherin, Cadherin-1

Specifications for CD324 (E-Cadherin) Antibody, anti-human, REAfinity™

Overview

Clone REA1319 recognizes human CD324, also known as E-cadherin or cadherin-1, which is a calcium-dependent cell adhesion protein found in adherence junctions of epithelial cells, e.g., in colon, uterus, liver, keratinocytes, etc. E-cadherin also serves as a ligand for integrin α-E/β-7. The epitope is expressed by a variety of carcinoma-derived cell lines such as MCF-7, HT-29, T-47D, NTERA-2, and 2102Ep. Loss of E-cadherin is thought to enable metastasis by disrupting intercellular contacts – an early step in metastatic dissemination. Furthermore, E-cadherin is a marker of undifferentiated embryonic stem (ES) cells and induced pluripotent stem (iPS) cells. For these cells, E-cadherin plays a major role in conveying cell survival signals. Mutations in CD324, which lead to loss of function or expression has been implicated in cancer progression and metastasis. Additional information: Clone REA1319 displays negligible binding to Fc receptors.

Alternative names

CDH1, Arc-1, CDHE, ECAD, LCAM, UVO, E-Cadherin, Cadherin-1

Detailed product information

Technical specifications

CloneREA1319
Clonalitymonoclonal
Isotyperecombinant human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD324 (E-Cadherin)
Alternative names of antigenCDH1, Arc-1, CDHE, ECAD, LCAM, UVO, E-Cadherin, Cadherin-1
Distribution of antigenepithelial cells, stem cells, colon, liver

Resources for CD324 (E-Cadherin) Antibody, anti-human, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

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