CD134 (OX40) Antibody, anti-mouse
Clone:
OX-86
Type of antibody:
Primary antibodies, Functional-grade antibodies
Isotype:
rat IgG1κ
Applications:
FA, FC
Alternative names:
TNFRSF4, Ly-70, OX-40, Txgp1l, Txgp1, ACT35

Specifications for CD134 (OX40) Antibody, anti-mouse

Overview

The CD134 antigen, also known as OX40 receptor, is a 50 kDa type I membrane glycoprotein of the TNF/NGF receptor superfamily. It is expressed on activated mouse T cells and B cells. The OX40 receptor binds to the OX40 ligand (CD252) to provide a costimulatory signal which is independent of CD28. The OX-86 monoclonal antibody does not block this interaction and is reported to provide costimulation signals to T cells.

Alternative names

TNFRSF4, Ly-70, OX-40, Txgp1l, Txgp1, ACT35

Detailed product information

Technical specifications

CloneOX-86
Clonalitymonoclonal
Isotyperat IgG1κ
Isotype controlIsotype Control Antibody, rat IgG1
Hostrat
Type of antibodyPrimary antibodies, Functional-grade antibodies
Speciesmouse
AntigenCD134 (OX40)
Alternative names of antigenTNFRSF4, Ly-70, OX-40, Txgp1l, Txgp1, ACT35
Molecular mass of antigen [kDa]28
Distribution of antigenB cells, endothelial cells, fibroblasts, lymphocytes, T cells
Entrez Gene ID22163
RRIDAB_2654948, AB_2654949, AB_2654950, AB_2654920

Resources for CD134 (OX40) Antibody, anti-mouse

Certificates

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References for CD134 (OX40) Antibody, anti-mouse

Publications

  1. Akiba, H. et al. (1999) CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells. J. Immunol. 162(12): 7058-7066
  2. Kjaergaard, J. et al. (2001) Augmentation versus inhibition: effects of conjunctional OX-40 receptor monoclonal antibody and IL-2 treatment on adoptive immunotherapy of advanced tumor. J. Immunol. 167: 6669-6677
  3. al-Shamkhani, A. et al. (1996) OX40 is differentially expressed on activated rat and mouse T cells and is the sole receptor for the OX40 ligand. Eur. J. Immunol. 26(8): 1695-1699

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