Benefit from our column-based technology using nano-sized beads for positive cell selection or cell depletion from any starting material, including peripheral blood mononuclear cells (PBMCs), whole blood, bone marrow, leukopak, and buffy coat.
MACS Column-based technology owes its longstanding success to the combination of superparamagnetic nano-sized beads and a very high magnetic gradient in our MACS Columns. This combination allows for minimal labeling of target cells and therefore preservation of cell integrity and characteristics. MACS MicroBeads are biodegradable and compatible with all downstream applications, including cell sorting, flow analysis, cell culture, functional assays and molecular analysis.
The high magnetic gradient generated by the matrix in the MACS Column allows for minimal labeling of target cells with nano-sized MicroBeads. This ensures that plenty of surface epitopes remain free for subsequent fluorescent staining and flow cytometry analysis.
Depletion of unwanted cells with MACS MicroBead Technology is an elegant way to obtain pure untouched target cells. Minimal labeling of unwanted cells with MACS MicroBeads avoids non-specific labeling of target cells, leaving target cells truly untouched. In contrast, column-free methods using nano-sized beads require high concentrations of labeling reagents thus risking non-specific labeling of the target cell fraction.
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