Type of antibody:
Primary antibodies, Recombinant antibodies
recombinant human IgG1
Alternative names:
CD365, HAVCR, HAVcr-1, KIM-1, TIMD-1, TIM, TIM1

Specifications for TIM-1 Antibody, anti-human, REAfinity™


Clone REA384 recognizes the human T cell immunoglobulin mucin receptor 1 (TIM-1) antigen, a single-pass type I membrane protein also known as hepatitis A virus cellular receptor 1 (HAVcr-1) or kidney injury molecule 1 (KIM-1). TIM-1 is widely expressed, with highest levels in kidney and testis. It is also expressed by activated T cells, B cells, natural killer T cells, and dendritic cells. The TIM gene family is involved in a variety of immunity related processes including T cell proliferation and survival, tissue inflammation, and atopy. In mice, eight TIM genes encode the proteins TIM-1 to TIM-8, whereas only three TIM genes are found in humans encoding TIM-1, TIM-3, and TIM-4. Several lines of evidence suggest that TIM-1 regulates T cell activity
in vivo
through responses mediated by Tʜ1, Tʜ2, Tʜ17, and regulatory T cells. TIM-1 is recruited to the T cell receptor signaling complex and has a costimulatory role. In addition to serving as a receptor for filoviruses, human TIM-1 is reported to serve as a receptor for hepatitis A virus and a variety of flaviviruses, alphaviruses, and arenaviruses.
Additional information: Clone REA384 displays negligible binding to Fc receptors.

Alternative names

CD365, HAVCR, HAVcr-1, KIM-1, TIMD-1, TIM, TIM1

Detailed product information

Technical specifications

Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hosthuman cell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Alternative names of antigenCD365, HAVCR, HAVcr-1, KIM-1, TIMD-1, TIM, TIM1
Molecular mass of antigen [kDa]37
Distribution of antigenT cells, NK cells, B cells, dendritic cells, kidney
Entrez Gene ID26762
RRIDAB_2889786, AB_2889785, AB_2654141, AB_2654142, AB_2654145, AB_2654146, AB_2654147, AB_2654148, AB_2654149, AB_2654150, AB_2654151, AB_2654152, AB_2889787

Resources for TIM-1 Antibody, anti-human, REAfinity™


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References for TIM-1 Antibody, anti-human, REAfinity™


  1. Angiar, I. S. et al. (2014) TIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunity. Immunity 40(4): 542-553
  2. Feigelstock, D. et al. (1998) The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor. J. Virol. 72(8): 6621-6628
  3. Moller-Tank, S. et al. (2013) Role of the phosphatidylserine receptor TIM-1 in enveloped-virus entry. J. Virol. 87(15): 8327-8341

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