Type of antibody:
Primary antibodies, Recombinant antibodies
recombinant human IgG1
Alternative names:
Klra6, Lymphocyte antigen 49f, T-cell surface glycoprotein Ly-49F

Specifications for Ly-49F Antibody, anti-mouse, REAfinity™


Clone REA1021 recognizes the mouse Ly-49F antigen (killer cell lectin-like receptor 6), a type II transmembrane natural killer (NK) cell receptor belonging to the Ly-49 family. Members of the Ly-49 family are homodimeric C-type lectin receptors, recognizing MHC class I molecules as ligands and include activating and inhibitory receptor molecules. The inhibitory receptor Ly-49F is expressed on subsets of NK cells, NK-T cells, and on a subpopulation of memory T cells in C57BL/6 mice, but not AKR/J, BALB/c, C3H/HeN, DBA/1, or SJL mice. IL-21 selectively down-regulates Ly-49F on mature NK cells.
Additional information: Clone REA1021 displays negligible binding to Fc receptors.

Alternative names

Klra6, Lymphocyte antigen 49f, T-cell surface glycoprotein Ly-49F

Detailed product information

Technical specifications

Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hosthuman cell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Alternative names of antigenKlra6, Lymphocyte antigen 49f, T-cell surface glycoprotein Ly-49F
Molecular mass of antigen [kDa]31
Distribution of antigenNK cells, T cells, NKT cells
Entrez Gene ID16637
RRIDAB_2727853, AB_2727891, AB_2727854, AB_2727892, AB_2727855, AB_2727893, AB_2727856, AB_2727894, AB_2727857, AB_2727895, AB_2727858, AB_2727896, AB_2727859, AB_2727897, AB_2727860, AB_2727898, AB_2727861, AB_2727890

Resources for Ly-49F Antibody, anti-mouse, REAfinity™


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References for Ly-49F Antibody, anti-mouse, REAfinity™


  1. Smith, H. R. et al. (1994) Ly-49 multigene family expressed by IL-2-activated NK cells. J. Immunol. 153(3): 1068-1079
  2. Hanke, T. et al. (1999) Direct assessment of MHC class I binding by seven Ly49 inhibitory NK cell receptors. Immunity 11(1): 67-77
  3. Gays, F. et al. (2005) Multiple cytokines regulate the NK gene complex-encoded receptor repertoire of mature NK cells and T cells. J. Immunol. 175(5): 2938-2947

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