Clone:
REA116
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
TBR-2

Specifications for EOMES Antibody, anti-mouse, REAfinity™

Overview

Clone REA116 recognizes EOMES, also known as T-box brain protein 2 (TBr2) or eomesodermin. EOMES is a 72–74 kDa T-box transcription factor and plays a crucial role in development including trophoblast differentiation, gastrulation, brain development, and cell-mediated immunity in adults. EOMES lacking embryos are arrested at the blastocyst stage due to differentiation defects of the trophoectoderm. As a regulator of cell mediated immunity, expression of EOMES is shown to be increased in effector CD8
+
T cells, in response to infection. Further, EOMES including its paralogue T-bet are suggested to be involved in NK cell maturation.
Additional information: Clone REA116 displays negligible binding to Fc receptors.

Alternative names

TBR-2

Detailed product information

Technical specifications

CloneREA116
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hosthuman cell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenEOMES
Alternative names of antigenTBR-2
Molecular mass of antigen [kDa]75
Entrez Gene ID13813
RRIDAB_2905193, AB_2651632, AB_2651633

Resources for EOMES Antibody, anti-mouse, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for EOMES Antibody, anti-mouse, REAfinity™

Publications

  1. Gordon, S. M. et al. (2012) The transcription factors T-bet and Eomes control key checkpoints of natural killer cell maturation. Immunity 36(1): 55-67
  2. Pearce, E. L. et al. (2003)
    Control of effector CD8
    +
    T cell function by the transcription factor Eomesodermin.
    Science 302: 1041
  3. Kidder, B. L. et al. (2010) Examination of transcriptional networks reveals an important role for TCFAP2C, SMARCA4, and EOMES in trophoblast stem cell maintenance. Genome Res. 20: 458-472

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