Clone:
REA991
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
ICOSLG, B7-H2, B7H2, B7RP-1, GL50, ICOSL, LICOS

Specifications for CD275 (B7-H2) Antibody, anti-human, REAfinity™

Overview

Clone REA991 recognizes the human CD275 antigen, also known as B7-H2, ICOSL, or GL50, a member of the B7 family of co-stimulatory molecules involved in regulating T cell activation and effector functions. It belongs to the Ig superfamily and has a predicted molecular weight of 40 kDa. CD275 is a ligand of inducible co-stimulator (ICOS) expressed on activated T cells. ICOS mediated co-stimulation promotes T helper (Tʜ) cell differentiation via Tʜ2 cytokine production such as interleukin 10 (IL-10) and IL-4. Human CD275 is expressed on B cells, dendritic cells, endothelial cells, renal tubular epithelial cells, activated monocytes, and human airway epithelial cells.
Additional information: Clone REA991 displays negligible binding to Fc receptors.

Alternative names

ICOSLG, B7-H2, B7H2, B7RP-1, GL50, ICOSL, LICOS

Detailed product information

Technical specifications

CloneREA991
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD275 (B7-H2)
Alternative names of antigenICOSLG, B7-H2, B7H2, B7RP-1, GL50, ICOSL, LICOS
Molecular mass of antigen [kDa]31
Distribution of antigenB cells, dendritic cells, endothelial cells, epithelial cells, monocytes, other
Entrez Gene ID23308
RRIDAB_2727687, AB_2727761, AB_2727688, AB_2727762, AB_2727689, AB_2727763, AB_2727690, AB_2727764, AB_2727691, AB_2727765, AB_2727692, AB_2727766, AB_2727693, AB_2727760

References for CD275 (B7-H2) Antibody, anti-human, REAfinity™

Publications

  1. Wang, S. et al. (2000) Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS. Blood 96(8): 2808-2813
  2. Qian, X. et al. (2006) The ICOS-ligand B7-H2, expessed on human type II alveolar epithelial cells, plays a role in the pulmonary host defense system. Eur. J. Immunol. 36(4): 906-918
  3. Kurosawa, S. et al. (2003) Expression of the costimulatory molecule B7-H2 (inducible costimulator ligand) by human airway epithelial cells. Am. J. Respir. Cell Mol. Biol. 28: 563-573

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