Clone:
REA563
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IHC, IF
Alternative names:
ME491, Tspan30

Specifications for CD63 Antibody, anti-mouse, REAfinity™

Overview

Clone REA563 recogizes the mouse CD63 antigen. It belongs to the tetraspanin transmembrane 4 superfamily (TM4SF) of proteins, which are characterized by four membrane spanning domains. Tetraspanins, via various homotypic and heterotypic interactions, regulate the spatial location and trafficking of associated transmembrane partners, eventually regulating and co-ordinating various signaling pathways. Interaction of CD63 with other membrane proteins or adaptors regulates cell activities such as adhesion, migration, and degranulation. CD63 is expressed on monocytes, macrophages, endothelium, fibroblasts, osteoclasts, smooth muscle cells, and activated platelets.
Additional information: Clone REA563 displays negligible binding to Fc receptors

Alternative names

ME491, Tspan30

Detailed product information

Technical specifications

CloneREA563
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD63
Alternative names of antigenME491, Tspan30
Molecular mass of antigen [kDa]26
Distribution of antigenendothelial cells, macrophages, monocytes, fibroblasts, osteoblasts, platelets, smooth muscle
Entrez Gene ID12512
RRIDAB_2658900, AB_2658901, AB_2658904, AB_2658905, AB_2658906, AB_2658907

Resources for CD63 Antibody, anti-mouse, REAfinity™

Certificates

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References for CD63 Antibody, anti-mouse, REAfinity™

Publications

  1. Kraft, S. et al. (2013) The tetraspanin CD63 is required for efficient IgE-mediated mast cell degranulation and anaphylaxis. J. Immunol. 191(6): 2871-2878
  2. Doyle, E. L. et al. (2011) CD63 is an essential cofactor to leukocyte recruitment by endothelial P-selectin. Blood 118(15): 4265-4273
  3. Miyamoto, H. et al. (1994) Molecular cloning of the murine homologue of CD63/ME491 and detection of its strong expression in the kidney and activated macrophages. Biochim. Biophys. Acta 1217(3): 312-316

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