Type of antibody:
Primary antibodies, Recombinant antibodies
recombinant human IgG1
Alternative names:
MCAM, MUC18, Endo-CAM, Mel-CAM, S-endo

Specifications for CD146 Antibody, anti-human, REAfinity™


Clone REA773 recognizes the human CD146 antigen, also known as MUC18, MCAM, Mel-CAM, or S-Endo-1. CD146 is a transmembrane glycoprotein belonging to the immunoglobulin superfamily and contains five extracellular immunoglobulin (Ig)-like domains. CD146 possesses a limited tissue expression distribution, including endothelial cells, pericytes, smooth muscle cells, follicular dendritic cells, melanoma cells, and a sub-population of activated T lymphocytes. CD146 is also expressed on marrow stromal cells (MSCs). CD146 functions as a Ca
-independent cell adhesion molecule that is involved in heterophilic cell-cell interactions, and may be involved in the extravasion and/or homing of activated T cells. CD146 expression in melanoma is also directly associated with tumor growth and metastasis.
Additional information: Clone REA773 displays negligible binding to Fc receptors.

Alternative names

MCAM, MUC18, Endo-CAM, Mel-CAM, S-endo

Detailed product information

Technical specifications

Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Alternative names of antigenMCAM, MUC18, Endo-CAM, Mel-CAM, S-endo
Molecular mass of antigen [kDa]69
Distribution of antigenT cells
Entrez Gene ID4162
RRIDAB_2655177, AB_2655178, AB_2655179, AB_2655180, AB_2655181, AB_2655182, AB_2655183, AB_2655184, AB_2655185, AB_2655176

Resources for CD146 Antibody, anti-human, REAfinity™


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References for CD146 Antibody, anti-human, REAfinity™


  1. Pickl, W. F. et al. (1997) MUC18/MCAM (CD146), an activation antigen of human T lymphocytes. J. Immunol. 158: 2107-2115
  2. Shih, J. M. (1999) The role of CD146 (Mel-CAM) in biology and pathology. J. Pathol. 189(1): 4-11
  3. Satyamoorthy, K. et al. (2001) Mel-CAM-specific genetic suppressor elements inhibit melanoma growth and invasion through loss of gap junctional communication. Oncogene 20: 4676-4684
  4. Bardin, N. et al. (2001) Identification of CD146 as a component of the endothelial junction involved in the control of cell-cell cohesion. Blood 98: 3677-3684
  5. Yan, Y. et al. (2003) Pathogenesis of autoimmunity after xenogeneic thymus transplantation. J. Immunol. 170: 5936-5946
  6. Mueller, I. et al. (2006) Animal serum-free culture conditions for isolation and expansion of multipotent mesenchymal stromal cells from human BM. Cytotherapy 8: 437-444

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