Therapeutic plasma exchange (TPE) facilitates the unselective removal of pathogenic substances from the patient’s plasma. Such pathogens include paraproteins, autoantibodies, immune complexes, protein-bound toxins, and mediators of inflammation.
During TPE the plasma is separated from cellular blood components by the LIFE 21
®
apheresis unit. The plasma is discarded and replaced by substitution solutions. Usually, 1–1.5 times the patient’s plasma volume is exchanged in a session.

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