Type of antibody:
Primary antibodies, Recombinant antibodies
recombinant human IgG1
Alternative names:
Notch 2, hN2

Specifications for Notch2 Antibody, anti-human, REAfinity™


Clone REA1204 recognizes human Notch2, a member of the Notch receptor family. Upon binding its membrane-bound ligand of the Delta-like or Jagged family members (Jagged1, Jagged2, and Delta1), the Notch receptor undergoes two proteolytic cleavage steps eventually releasing the Notch intracellular domain (NICD), which subsequently translocates into the nucleus, where it activates transcription within a multiprotein complex. The Notch signaling is essential for the physiologic development of natural killer (NK) cells. Notch2 is expressed on various hematopetic cells, including T cell precursors in the thymus and activated peripheral T cells. In addition, the altered expression of Notch2 in various leukemias, lymphomas, and cancers has been reported.
Additional information: Clone REA1204 displays negligible binding to Fc receptors.

Alternative names

Notch 2, hN2

Detailed product information

Technical specifications

Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hosthuman cell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, non-human primate
african green monkey (
Chlorocebus aethiops
Alternative names of antigenNotch 2, hN2
Molecular mass of antigen [kDa]263
Distribution of antigenT cells, tumor cells, lymphoma, leukemia cells, thymocytes, other
Entrez Gene ID4853
RRIDAB_2811423, AB_2811429, AB_2811424, AB_2811430, AB_2811425, AB_2811431, AB_2811426, AB_2811432, AB_2811427, AB_2811428

Resources for Notch2 Antibody, anti-human, REAfinity™


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References for Notch2 Antibody, anti-human, REAfinity™


  1. Haraguchi, K. et al. (2009) Notch activation induces the generation of functional NK cells from human cord blood CD34-positive cells devoid of IL-15. J. Immunol. 182(10): 6168-6178
  2. Gray, G. E. et al. (1999) Human ligands of the Notch receptor. Am. J. Pathol. 154(3): 785-794

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