Clone:
REA320
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, MICS, IF, IHC, 3D-IF
Alternative names:
ANOP3, MCOPS3, lcc, ysb

Specifications for Sox2 Antibody, anti-human/mouse, REAfinity™

Overview

Clone REA320 recognizes the human and mouse Sox2 antigen, a member of the SRY-related HMG-box family of transcription factors. The SRY-containing protein Sox2 is known to regulate the self-renewal of mouse and human embryonic stem cells. It is also important for the maintenance of stem cells in multiple adult tissues including brain and trachea, and it is one of the key transcription factors for establishing induced pluripotent stem cells. Sox2 forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1, and ZFP206. Overexpression and gene amplification of Sox2 have been associated with the development of squamous cell carcinoma in multiple tissues such as the lung and esophagus.
Additional information: Clone REA320 displays negligible binding to Fc receptors.

Alternative names

ANOP3, MCOPS3, lcc, ysb

Detailed product information

Technical specifications

CloneREA320
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse
AntigenSox2
Alternative names of antigenANOP3, MCOPS3, lcc, ysb
Molecular mass of antigen [kDa]34
Distribution of antigenbrain, lung
Entrez Gene ID6657
RRIDAB_2784458, AB_2784461, AB_2784460, AB_2751040, AB_2784459

Resources for Sox2 Antibody, anti-human/mouse, REAfinity™

Certificates

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References for Sox2 Antibody, anti-human/mouse, REAfinity™

Publications

  1. Liu, K. et al. (2013) The multiple roles for Sox2 in stem cell maintenance and tumorigenesis. Cell. Signal. 25(5): 1264-1271
  2. Fantes, J. et al. (2003) Mutations in SOX2 cause anophthalmia. Nat. Genet. 33(4): 461-463
  3. Maucksch, C. et al. (2013) Concise review: the involvement of SOX2 in direct reprogramming of induced neural stem/precursor cells. Stem Cells Transl Med 2(8): 579-583

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