Clone:
REA314
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, MICS, IF, IHC
Alternative names:
Homeobox protein NANOG, ES cell-associated protein 4, Early embryo specific expression NK-type homeobox protein, Homeobox transcription factor Nanog (hNanog)

Specifications for Nanog Antibody, anti-human, REAfinity™

Overview

Clone REA314 recognizes the human Nanog antigen, a homeobox transcription factor also known as ES cell–associated protein 4. Nanog is thought to be a key factor in maintaining pluripotency. It is expressed in the central portion of the morula, the inner cell mass of the blastocyst, in embryonic stem cells (ESC), and embryonic germ cells (EGC). The expression decreases with ESC differentiation. Nanog is thought to function in concert with other factors such as Oct-4 and SOX2 to establish ESC identity. Inhibition of Nanog expression has led to a reduction in tumorigenicity and such
in vitro
characteristics of stem cells as anchorage independent growth whereas overexpression may increase tumorigenicity.
Additional information: Clone REA314 displays negligible binding to Fc receptors.

Alternative names

Homeobox protein NANOG, ES cell-associated protein 4, Early embryo specific expression NK-type homeobox protein, Homeobox transcription factor Nanog (hNanog)

Detailed product information

Technical specifications

CloneREA314
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenNanog
Alternative names of antigenHomeobox protein NANOG, ES cell-associated protein 4, Early embryo specific expression NK-type homeobox protein, Homeobox transcription factor Nanog (hNanog)
Molecular mass of antigen [kDa]35
Distribution of antigenstem cells, ES and iPS cells
Entrez Gene ID79923
RRIDAB_2751383, AB_2784440, AB_2784439, AB_2652992, AB_2751394

Resources for Nanog Antibody, anti-human, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for Nanog Antibody, anti-human, REAfinity™

Publications

  1. Costa, Y. et al. (2013) NANOG-dependent function of TET1 and TET2 in establishment of pluripotency. Nature 495(7441): 370-374
  2. Wang, Z. et al. (2012) Distinct lineage specification roles for NANOG, OCT4, and SOX2 in human embryonic stem cells. Cell Stem Cell 10(4): 440-454
  3. Chambers, I. et al. (2003) Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 113(5): 643-655

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