Umbilical cord-derived mesenchymal stem cells (MSCs)

Human umbilical cord tissue can be dissociated into a single-cell suspension by combining mechanical dissociation with enzymatic degradation of the extracellular adhesion proteins that maintain the tissue's structural integrity. Our Umbilical Cord Dissociation Kit, human and the gentleMACS Dissociators are the perfect combination for standardized and reliable dissociation of umbilical cord tissue.

Our cell culture options provide reliable solutions for the maintenance and expansion of MSCs with preserved differentiation potential and immunomodulation ability.

The MSC Phenotyping Kit was developed for the standardized identification and phenotyping of cultured human MSCs by flow cytometry based on the defined ISCT standards.

The suppression potential of MSCs varies among in vitro expanded cells and shows donor-dependent differences. MSCs can be “licensed” by inflammatory cytokines such IFN-γ and TNF-α to become more immunosuppressive and show a more homogeneous phenotype in this regard. The MSC Suppression Inspector, human was developed for standardized characterization of the immunomodulatory function of MSCs by co-culture with CD4⁺CD25^– or CD4⁺ responder T (Tresp) cells.