Clone:
REA157
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, ICC
Alternative names:
PODXL, Gp200, PC, PCLP, PCLP-1, Podocalyxin

Specifications for TRA-1-60 Antibody, anti-human, REAfinity™

Overview

Clone REA157 recognizes the TRA-1-60 antigen, a neuraminidase-resistant carbohydrate epitope expressed on podocalyxin, which is a transmembrane glycoprotein. Podocalyxin is a member of the CD34-related family of sialomucins and is recognized as a stem cell and tumor marker. TRA-1-60 antigen is expressed on the surface of human embryonic stem cells (ESC), embryonic germ cells (EG), and embryonic carcinoma cells (EC). Expression of TRA-1-60 is lost upon differentiation and thus it can be used to assess the differentiation stage of the cells. TRA-1-60 can be detected in the serum of patients with germ cell tumors which contain an EC component.
Additional information: Clone REA157 displays negligible binding to Fc receptors.

Alternative names

PODXL, Gp200, PC, PCLP, PCLP-1, Podocalyxin

Detailed product information

Technical specifications

CloneREA157
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenTRA-1-60
Alternative names of antigenPODXL, Gp200, PC, PCLP, PCLP-1, Podocalyxin
Distribution of antigenstem cells, ES and iPS cells
RRIDAB_2801969, AB_2654228, AB_2801990

Resources for TRA-1-60 Antibody, anti-human, REAfinity™

Certificates

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References for TRA-1-60 Antibody, anti-human, REAfinity™

Publications

  1. Andrews, P. W. et al. (1984) Three monoclonal antibodies defining distinct differentiation antigens associated with different high molecular weight polypeptides on the surface of human embryonal carcinoma cells. Hybridoma 3(4): 347-361
  2. Lajer, H. et al. (2002) Clinical use of serum TRA-1-60 as tumor marker in patients with germ cell cancer. Int. J. Cancer 100(2): 244-246
  3. Schopperle, W. M. et al. (2007) The TRA-1-60 and TRA-1-81 human pluripotent stem cell markers are expressed on podocalyxin in embryonal carcinoma. Stem Cells 25(3): 723-730

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