MACSQuant® Tyto® Cell Sorter

The revolution in cell sorting has begun

The MACSQuant® Tyto® is revolutionizing cell sorting. Our patented microchip-based technology opens new possibilities in basic research and medical applications. Start taking advantage of high-speed, multiparameter flow sorting in the safety of a fully enclosed cartridge.

 

Benefits

Full sterility

Samples are kept contamination-free within the disposable, fully closed MACSQuant Tyto Cartridge. No risk for carry-over or contamination of fluidics.

Fast and easy handling

No drop delay or laser alignment needed. Simply insert the cartridge, gate on cells, and sort.

Completely safe

The fully closed cartridge prevents aerosol and droplet formation, providing a safe environment for operator and sample.

Gentle to cells

Sort and even re.sort cells under low pressure without compromising cell viability or functionality. Cells are no longer exposed to high pressure, charge, or decompression.

 

Features & specifications

MACSQuant Tyto

Software

Intuitive interface that supports an easy experimental setup with many automated features, resulting in true walkaway cell sorting procedure

Loading chamber

Temperature-controlled loading chamber that keeps samples at stable temperature between 4–25 °C throughout the whole sorting process

Touchscreen monitor

Additional touchscreen monitor for convenient operation and surveillance of the system

Barcode scanner

Integrated barcode scanning for immediate identification of cartridge type and lot, resulting in e.g. automated cartridge alignment

10 parameters

3 lasers, 8 fluorescent channels, and 2 scatter channels allow for complex sorting strategies with up to 10-parameters

MACSQuant Tyto Cartridge

Closed cartridge system for sterile and safe cell sorting procedures

1 2 3 4 5 6

Software

Intuitive interface that supports an easy experimental setup with many automated features, resulting in true walkaway cell sorting procedure

Loading chamber

Temperature-controlled loading chamber that keeps samples at stable temperature between 4–25 °C throughout the whole sorting process

Touchscreen monitor

Additional touchscreen monitor for convenient operation and surveillance of the system

Barcode scanner

Integrated barcode scanning for immediate identification of cartridge type and lot, resulting in e.g. automated cartridge alignment

MiniSampler

10 parameters

3 lasers, 8 fluorescent channels, and 2 scatter channels allow for complex sorting strategies with up to 10-parameters

MiniSampler

MACSQuant Tyto Cartridge

Closed cartridge system for sterile and safe cell sorting procedures

MACSQuant Tyto

Brochures/posters

Scientific posters

App notes/customer reports

  • Carstensen, L. et al. (2019) Long-Term Exposure to Inflammation Induces Differential Cytokine Patterns and Apoptosis in Dendritic Cells. Front Immunol 10(2702): 2709
  • Burgoyne, P. et al. (2021)
    CCR7
    +
    dendritic cells sorted by binding of CCL19 show enhanced Ag-presenting capacity and antitumor potency.
    J. Leukoc. Biol. 111(6): 1243-1251
  • Radke, S. et al. (2020)
    Purification of Human CD34
    +
    CD90
    +
    HSCs Reduces Target Cell Population and Improves Lentiviral Transduction for Gene Therapy.
    Mol Ther Methods Clin Dev. 18: 679-691
  • Ötztürk, . E. et al. (2021) scAAVengr, a transcriptome-based pipeline for quantitative ranking of engineered AAVs with single-cell resolution. Elife 10: e64175
  • Bacher, P. et al. (2020)
    Low avidity CD4
    +
    T cell responses to SARS-CoV-2 in unexposed individuals and humans with severe COVID-19.
    Immunity 53: 1258-1271
  • Jonsson, A. et al. (2020) Transcriptional profiles of human islet and exocrine endothelial cells in subjects with or without impaired glucose metabolism Sci Rep 10(1): 22315
  • Zhou, H. et al. (2021) Identifying the functions of two biomarkers in human oligodendrocyte progenitor cell development. J. Transl. Med. 19(1): 188
  • Dugan, H. L. et al. (2021) Profiling B cell immunodominance after SARS-CoV-2 infection reveals antibody evolution to non-neutralizing viral targets. Immunity 54(6): 1290-1303
  • Roberts, L. M. et al. (2021) Cutting Edge: Lung-Resident T Cells Elicited by SARS-CoV-2 Do Not Mediate Protection against Secondary Infection. J. Immunol. 207(10): 2399-2404
  • Shu, R. et al. (2021) Engineered CAR-T cells targeting TAG-72 and CD47 in ovarian cancer. Mol Ther Oncolytics 20: 325-341
  • Fattorelli, N. et al. (2021) Stem-cell-derived human microglia transplanted into mouse brain to study human disease. Nat Protoc. 16(2): 1013-1033
  • Ou, K. et al. (2021) Strong Expansion of Human Regulatory T Cells for Adoptive Cell Therapy Results in Epigenetic Changes Which May Impact Their Survival and Function. Front Cell Dev Biol. 9: 751590
  • Roberts, L. M. et al. (2020) Validation and Application of a Bench Top Cell Sorter in a BSL-3 Containment Setting. bioRxiv : doi: 10.1101/2020.07.30.229146 (preprint)
  • Marongiu, L. et al. (2022) Maturation signatures of conventional dendritic cell subtypes in COVID-19 suggest direct viral sensing. Eur J Immunol. 52(1): 109-122
  • Zazhytska, M. et al. (2022) Non-cell-autonomous disruption of nuclear architecture as a potential cause of COVID-19-induced anosmia. Cell 185(6): 1052-1064
  • Haruna, M. et al. (2022)
    The impact of CCR8
    +
    regulatory T cells on cytotoxic T cell function in human lung cancer
    Sci Rep 12(1): 5377
  • Wang, Z. et al. (2022) Efficient recovery of potent tumour-infiltrating lymphocytes through quantitative immunomagnetic cell sorting. Nat Biomed Eng 6(2): 108-117
  • Ocanas, S. R. et al. (2022)
    Minimizing the
    Ex Vivo
    Confounds of Cell-Isolation Techniques on Transcriptomic and Translatomic Profiles of Purified Microglia.
    eNeuro 9(2): 0348
 

Applications

Application note

Clinical Treg sorting on MACSQuant® Tyto®​

Treg-based therapy shows an enormous potential for treatment of various diseases. Discover how two of our best technologies team up to provide you with the tools for every step on your journey: reliable and trustworthy research materials alongside an easily translatable workflow into the clinic.​ 

  • Pre-enrichment of CD25+ cells with the CliniMACS Prodigy®​ 
  • GMP-compliant Treg sorting on the MACSQuant Tyto Cell Sorter​
Explore the workflow
 

Software

Cell sorting has never been easier with the MACSQuantify™ Tyto Software 1.0

  • Press play and walk away: No hands-on during sort process
  • No additional skills needed: Sorting is as simple as operating a MACSQuant® Analyzer
  • Maximal flexibility in panel design and usage of bright and dim markers
  • High sort rates with increased yield and purity
  • Automatically generated run reports including real-time sort statistics and instrument settings
See our software solutions
 

Support

Support at your fingertips

MACSQuant® Tyto® Cell Sorter

The revolution in cell sorting has begun
Order no.: 130-103-931. For research use only. 

Request a quote Schedule a demo

Related products for
MACSQuant
®
Tyto
®

6 products available | view all

Seems like you are coming from USA!
Do you want to visit our website in your country?