Clone:
REA411
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
SRK, STCD, STD, TZK, ZAP-70

Specifications for ZAP70 pY292 Antibody, anti-human, REAfinity™

Overview

Clone REA411 recognizes the human Zeta-chain-associated protein kinase 70 (ZAP70) antigen phosphorylated at tyrosine 292 (pY292). ZAP70 plays an essential role in regulation of the adaptive immune response. It is normally expressed near the surface membrane of T cells and natural killer cells. ZAP70 associates with the ζ subunit of the T cell antigen receptor, and plays a critical role in T cell–signaling. It regulates both T cell–activation switch on and switch off by modulating TCR expression at the T cell surface. During thymocyte development, ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection. Additionally, the ZAP70-dependent signaling pathway may also contribute to primary B cells formation and activation through the B cell receptor. Recruitment and activation of ZAP70 are transient and are terminated by phosphorylation of negative regulatory tyrosine residues and dephosphorylation of positively acting sites.
In vivo
analyses suggest that phosphorylation of residue Y292 plays a role in attenuation of TCR signaling.
Additional information: Clone REA411 displays negligible binding to Fc receptors.

Alternative names

SRK, STCD, STD, TZK, ZAP-70

Detailed product information

Technical specifications

CloneREA411
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenZAP70 pY292
Alternative names of antigenSRK, STCD, STD, TZK, ZAP-70
Molecular mass of antigen [kDa]70
Distribution of antigenT cells, NK cells
Entrez Gene ID7535
RRIDAB_2654301, AB_2654302, AB_2654303, AB_2654300

Resources for ZAP70 pY292 Antibody, anti-human, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for ZAP70 pY292 Antibody, anti-human, REAfinity™

Publications

  1. Arpaia, E. et al. (1994)
    Defective T cell receptor signaling and CD8
    +
    thymic selection in humans lacking zap-70 kinase.
    Cell 76(5): 947-958
  2. Chan, A. C. et al. (1992) ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain. Cell 71(4): 649-662
  3. Bottini, N. et al. (2002) Activation of ZAP-70 through specific dephosphorylation at the inhibitory Tyr-292 by the low molecular weight phosphotyrosine phosphatase (LMPTP). J. Biol. Chem. 277(27): 24220-24224

Related products for
ZAP70 pY292 Antibody, anti-human, REAfinity™

3 products available

Seems like you are coming from USA!
Do you want to visit our website in your country?