Clone:
REA569
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
FLT1, FLT

Specifications for VEGFR-1 (Flt-1) Antibody, anti-human, REAfinity™

Overview

Clone REA569 recognizes the human VEGFR-1 antigen, also known as Flt-1, belonging to the class III subfamily of receptor tyrosine kinases. Vascular endothelial growth factors (VEGFs) stimulate cellular responses by binding to tyrosine kinase receptors on the cell surface, causing them to dimerize, and become activated through transphosphorylation. VEGFs are produced by endothelial, hematopoietic, and stromal cells in response to hypoxia and upon stimulation by growth factors such as transforming growth factor beta (TGF-β), interleukins, or platelet-derived growth factors (PDGFs).
Additional information: Clone REA569 displays negligible binding to Fc receptors

Alternative names

FLT1, FLT

Detailed product information

Technical specifications

CloneREA569
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenVEGFR-1 (Flt-1)
Alternative names of antigenFLT1, FLT
Molecular mass of antigen [kDa]148
Distribution of antigenother
Entrez Gene ID2321
RRIDAB_2784491, AB_2819621, AB_2819617, AB_2654268, AB_2654269, AB_2784492

Resources for VEGFR-1 (Flt-1) Antibody, anti-human, REAfinity™

Certificates

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References for VEGFR-1 (Flt-1) Antibody, anti-human, REAfinity™

Publications

  1. Grunewald, F. S. et al. (2010) Structure-function analysis of VEGF receptor activation and the role of coreceptors in angiogenic signaling. Biochim. Biophys. Acta 1804(3): 567-580
  2. Riccioni, R. et al. (2007) Expression of Tie-2 and other receptors for endothelial growth factors in acute myeloid leukemias is associated with monocytic features of leukemic blasts. Stem Cells 25(8): 1862-1871
  3. Stuttfeld, E. et al. (2009) Structure and function of VEGF receptors. Int J Biochem Mol Biol 61(9): 915-922
  4. Shibuya, M. (2001) Structure and function of VEGF/VEGF-receptor system involved in angiogenesis. Cell Struct. Funct. 26(1): 25-35

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