Clone:
REA659
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
Grb2-associating protein, GASP, E430004N04Rik, SPOT, TSEPA, thylex

Specifications for THEMIS Antibody, anti-mouse, REAfinity™

Overview

Clone REA659 recognizes the mouse THEMIS antigen, a cytosolic protein also known as Gasp or Grb2-associating protein. THEMIS is only expressed in T cells, highly expressed in thymocytes, especially in immature CD4
+
/CD8
+
thymocytes, and lower expressed in mature T cells. THEMIS plays an important role in positive selection and in the development of single-positive thymocytes.
Additional information: Clone REA659 displays negligible binding to Fc receptors.

Alternative names

Grb2-associating protein, GASP, E430004N04Rik, SPOT, TSEPA, thylex

Detailed product information

Technical specifications

CloneREA659
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenTHEMIS
Alternative names of antigenGrb2-associating protein, GASP, E430004N04Rik, SPOT, TSEPA, thylex
Molecular mass of antigen [kDa]73
Distribution of antigenT cells
Entrez Gene ID210757
RRIDAB_2654136, AB_2654135

Resources for THEMIS Antibody, anti-mouse, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for THEMIS Antibody, anti-mouse, REAfinity™

Publications

  1. Lesourne, R. et al. (2009) Themis, a T cell-specific protein important for late thymocyte development. Nat. Immunol. 10(8): 840-847
  2. Fu, G. et al. (2009) Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling. Nat. Immunol. 10(8): 848-856
  3. Patrick, M. S. et al. (2009) Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes. Proc. Natl. Acad. Sci. U.S.A. 106(38): 16345-16350

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