Clone:
2-2B
Type of antibody:
Primary antibodies
Isotype:
mouse IgM
Applications:
FC, MICS, IF, IHC
Alternative names:
NCAM1, CD56, MSK39, NCAM, E-NCAM, NCAM-1, NCAM-C

Specifications for PSA-NCAM Antibody, anti-human/mouse/rat

Overview

The Anti-PSA-NCAM antibody recognizes an epitope on human, mouse, and rat polysialic acid (PSA) which, in vertebrates, is found linked to the extracellular domain of the neural cell adhesion molecule (NCAM, CD56). PSA-NCAM, the highly polysialated form of NCAM, is predominantly expressed in embryonic and neonatal neural tissue. In adult mammalian brain PSA-NCAM expression is restricted mainly to areas that retain neurogenic potential, such as the subventricular zone (SVZ) and the dentate gyrus of the hippocampus. PSA-NCAM is a marker for immature neuronal-committed progenitors that are permanently generated in the SVZ and migrate along a well-defined pathway, the rostral migratory stream, into the olfactory bulb where they differentiate into GABAergic and dopaminergic interneurons. Antibodies against PSA-NCAM have also been used to immunomagnetically isolate neuronal progenitors from postnatal mice and rat forebrain.

Alternative names

NCAM1, CD56, MSK39, NCAM, E-NCAM, NCAM-1, NCAM-C

Detailed product information

Technical specifications

Clone2-2B
Clonalitymonoclonal
Isotypemouse IgM
Isotype controlIsotype Control Antibody, mouse IgM
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman, mouse, rat
AntigenPSA-NCAM
Alternative names of antigenNCAM1, CD56, MSK39, NCAM, E-NCAM, NCAM-1, NCAM-C
RRIDAB_2727931, AB_2752096, AB_2727203

Resources for PSA-NCAM Antibody, anti-human/mouse/rat

Certificates

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References for PSA-NCAM Antibody, anti-human/mouse/rat

Publications

  1. Jungblut, M. et al. (2012) Isolation and characterization of living primary astroglial cells using the new GLAST-specific monoclonal antibody ACSA-1. Glia 60(6): 894-907
  2. G. Kantzer, C. et al. (2017) Anti-ACSA-2 defines a novel monoclonal antibody for prospective isolation of living neonatal and adult astrocytes. Glia 65(6): 990-1004
  3. Batiuk, M. Y. et al. (2017) An immunoaffinity-based method for isolating ultrapure adult astrocytes based on ATP1B2 targeting by the ACSA-2 antibody. J. Biol. Chem. 292(21): 8874-8891
  4. Rougon, G. and Marshak, D. R. (1986) Structural and immunological characterization of the amino-terminal domain of mammalian neural cell adhesion molecules. J. Biol. Chem. 261: 3396-3401
  5. Doetsch, F. et al. (1997) Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain. J. Neurosci. 17: 5046-5061
  6. Marmur, R. et al. (1998) Differentiation of oligodendroglial progenitors derived from cortical multipotent cells requires extrinsic signals including activation of gp130/LIFbeta receptors. J. Neurosci. 18: 9800-9811
  7. Seki, T. (2002) Expression patterns of immature neuronal markers PSA-NCAM, CRMP-4 and NeuroD in the hippocampus of young adult and aged rodents. J. Neurosci. Res. 70: 327-334
  8. Pennartz, S. et al. (2004) Purification of neuronal precursors from the adult mouse brain: comprehensive gene expression analysis provides new insights into the control of cell migration, differentiation, and homeostasis. Mol. Cell. Neurosci. 25: 692-706
  9. Seidenfaden, R. et al. (2006) Glial conversion of SVZ-derived committed neuronal precursors after ectopic grafting into the adult brain. Mol. Cell. Neurosci. 32: 187-198
  10. Metsuyanim, S. et al. (2009) Expression of stem cell markers in the human fetal kidney. PLoS One 4(68): e6709
  11. Kiss, J. Z. and Muller, D. (2001) Contribution of the neural cell adhesion molecule to neuronal and synaptic plasticity. Rev. Neurosci. 12: 297-310
  12. Seidenfaden et al. (2006) MACS&more 10(1): 4-6

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