Clone:
REA529
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
TP53, BCC7, LFS1, TRP53, NY-CO-13

Specifications for p53 acK382 Antibody, anti-human, REAfinity™

Overview

Clone REA529 recognizes the human cellular tumor antigen p53 acetylated in the C-terminal region at lysine 382 (acK382). The p53 protein is an important regulator of cell growth and, thus, functions as a tumor suppressor in many tumor types. The p53 tumor suppressor gene is altered or deleted in most solid human tumors. It is tightly regulated and plays a critical role in the cellular response to environmental stress. Upon a cell's exposure to stress, such as hypoxia or genomic damage, the p53 protein is expressed at high levels and is post-translationally modified. These modifications, which include phosphorylation, acetylation, and glycosylation occur rapidly and lead to the activation of p53, resulting in either G1 growth arrest or programmed cell death. The acetylation levels of p53 are significantly enhanced in response to stress and correlate well with p53 activation and stabilization. p53 acetylation at K382 plays an important role in depsipeptide-induced p21(Waf1/Cip1) expression.
Additional information: Clone REA529 displays negligible binding to Fc receptors.

Alternative names

TP53, BCC7, LFS1, TRP53, NY-CO-13

Detailed product information

Technical specifications

CloneREA529
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
Antigenp53 acK382
Alternative names of antigenTP53, BCC7, LFS1, TRP53, NY-CO-13
Molecular mass of antigen [kDa]44
Distribution of antigenother
Entrez Gene ID7157
RRIDAB_2653129, AB_2653130, AB_2653131, AB_2653128

Resources for p53 acK382 Antibody, anti-human, REAfinity™

Certificates

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References for p53 acK382 Antibody, anti-human, REAfinity™

Publications

  1. Zakut-Houri, R. et al. (1985) Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells. EMBO J. 4(5): 1251-1255
  2. Tang, Y. et al. (2008) Acetylation is indispensable for p53 activation. Cell 133(4): 612-626
  3. Zhao, Y. et al. (2006) Acetylation of p53 at lysine 373/382 by the histone deacetylase inhibitor depsipeptide induces expression of p21(Waf1/Cip1). Mol. Cell. Biol. 26(7): 2782-2790

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