Clone:
REA498
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
CTNND1, CAS, CTNND, p120cas, p120ctn, p120

Specifications for p120 Catenin pS288 Antibody, anti-human, REAfinity™

Overview

Clone REA498 recognizes the human p120 catenin antigen phosphorylated at serine 288 (pS288). p120 catenin exists as four isoforms that range in size from 90 to 115 kDa. Expression of these isoforms is heterogeneous in human carcinomas, suggesting that altered expression contributes to malignancy. p120 catenin is a prototypic member of subfamily of armadillo-domain (ARM) proteins. The p120 ARM domain displays 22% homology to other ARM-domain proteins such as β-catenin and plakoglobin, which are basically cadherin binding proteins, suggesting the involvement of p120 in binding to cadherin. p120 associates with most classical (type I) and nonclassical (type II) cadherins via ARM repeats 1–7 and is localized at the cell junctions, where it constitutes the cadherin complex. Functions of p120 include regulation of stability of cadherins and modulation of activity of rho GTPases in the cytoplasm. Phosphorylation of p120 catenin at multiple sites regulates its various functions and it can be phosphorylated by Src and various receptor tyrosine kinases.
Additional information: Clone REA498 displays negligible binding to Fc receptors.

Alternative names

CTNND1, CAS, CTNND, p120cas, p120ctn, p120

Detailed product information

Technical specifications

CloneREA498
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, non-human primate, other
Cross-reactivitymouse, monkey, dog
Antigenp120 Catenin pS288
Alternative names of antigenCTNND1, CAS, CTNND, p120cas, p120ctn, p120
Molecular mass of antigen [kDa]108
Distribution of antigenother
Entrez Gene ID1500
RRIDAB_2653103, AB_2653104, AB_2653105, AB_2653106, AB_2653107, AB_2653102

Resources for p120 Catenin pS288 Antibody, anti-human, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for p120 Catenin pS288 Antibody, anti-human, REAfinity™

Publications

  1. Alemà, S. et al. (2007) p120 catenin and phosphorylation: Mechanisms and traits of an unresolved issue. Biochim. Biophys. Acta 1773(1): 47-58
  2. Petrova, Y. et al. (2012) Conformational epitopes at cadherin calcium-binding sites and p120-catenin phosphorylation regulate cell adhesion. Mol. Biol. Cell 23(11): 2092-2108
  3. Takahashi, K. et al. (2014) CD148 tyrosine phosphatase promotes cadherin cell adhesion. PLoS One 9(11): e112753

Related products for
p120 Catenin pS288 Antibody, anti-human, REAfinity™

3 products available

Seems like you are coming from USA!
Do you want to visit our website in your country?