Clone:
REA297
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
ENK, ecat4, Early embryo specific expression NK-type homeobox protein

Specifications for Nanog Antibody, anti-mouse, REAfinity™

Overview

Clone REA297 recognizes the murine Nanog antigen, a homeobox transcription factor also known as ES cell-associated protein 4. Nanog is thought to be a key factor in maintaining pluripotency. It is expressed in the central portion of the morula, the inner cell mass of the blastocyst, in embryonic stem cells (ESC) and embryonic germ cells (EGC). The expression decreases with ESC differentiation. Nanog is thought to function in concert with other factors such as Oct-4 and SOX2 to establish ESC identity. Overexpression of Nanog in mouse ESC causes them to self-renew in the absence of Leukemia inhibitory factor. Loss of Nanog function causes differentiation of mouse ESC into other cell types.
Additional information: Clone REA297 displays negligible binding to Fc receptors.

Alternative names

ENK, ecat4, Early embryo specific expression NK-type homeobox protein

Detailed product information

Technical specifications

CloneREA297
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenNanog
Alternative names of antigenENK, ecat4, Early embryo specific expression NK-type homeobox protein
Molecular mass of antigen [kDa]34
Distribution of antigenstem cells, ES and iPS cells
Entrez Gene ID71950
RRIDAB_2652983, AB_2652984, AB_2652985, AB_2652986, AB_2652987, AB_2652982

Resources for Nanog Antibody, anti-mouse, REAfinity™

Certificates

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References for Nanog Antibody, anti-mouse, REAfinity™

Publications

  1. Mitsui et al. (2003) The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell 113: 631-642
  2. Lin, T. et al. (2005) p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression. Nat. Cell Biol. 7(2): 165-171
  3. Yates, A. et al. (2005) The homeodomain protein Nanog and pluripotency in mouse embryonic stem cells. Biochem. Soc. Trans. 33(6): 1518-1521

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