Clone:
REAL535
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF

Specifications for HLA-BC Antibody, anti-human, REAdye_lease™

Overview

Clone REAL535 is an antibody fragment derived from the full HLA-BC antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL535 recognizes the class I Human Leukocyte Antigens (HLA) B and C. Expressed on the surface of most nucleated cells, class I molecules are heterodimeric molecules and consist of a type I integral membrane α heavy chain and soluble β2 microglobulin protein. The extracellular region of the heavy chain further consists of 3 domains, one of which comprises the peptide binding groove. Antigens binding to class I molecules are 8-10 amino acids long and play an important role in recognition of the virus infected and malignant cells by cytotoxic T lymphocytes (CTLs). In addition, class I molecules interact with NK cell receptors to modulate the activity of NK cells.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Detailed product information

Technical specifications

CloneREAL535
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenHLA-BC
Distribution of antigenT cells, NK cells, spleen
RRIDAB_2857590, AB_2857586

Resources for HLA-BC Antibody, anti-human, REAdye_lease™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for HLA-BC Antibody, anti-human, REAdye_lease™

Publications

  1. Srivastava, R. et al. (1985) Molecular organization of the class I genes of human major histocompatibility complex. Immunol. Rev. 84: 93-121
  2. Parham, P. et al. (1996) Population biology of antigen presentation by MHC class I molecules. Science 272(5258): 67-74

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