Clone:
REA360
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
ITGA3, MSK18, FRP-2, GAP-B3, GAPB3, ILNEB, VCA-2, VL3A, VLA-3α

Specifications for CD49c Antibody, anti-human, REAfinity™

Overview

Clone REA360 recognizes the human CD49c antigen, a single-pass type I membrane protein also known as integrin α-3 (ITGA3) or VLA-3α. CD49c forms a heterodimer with integrin β1 (α3β1, CD49c/CD29, VLA-3) and plays a role in neural migration and corticogenesis, acted upon by such factors as netrin-1 and reelin. It is expressed by many types of adhesion cells, such as endothelial cells, epithelial cells, and dermal fibroblasts. Weak expression has been reported on leukocytes. CD49c/CD29 plays a role in cell-cell and cell-matrix adhesion through binding fibronectin, laminin, collagen, epiligrin, thrombospondin, and CSPG4.
Additional information: Clone REA360 displays negligible binding to Fc receptors.

Alternative names

ITGA3, MSK18, FRP-2, GAP-B3, GAPB3, ILNEB, VCA-2, VL3A, VLA-3α

Detailed product information

Technical specifications

CloneREA360
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD49c
Alternative names of antigenITGA3, MSK18, FRP-2, GAP-B3, GAPB3, ILNEB, VCA-2, VL3A, VLA-3α
Molecular mass of antigen [kDa]113(sum of molecular weights of subunits)
Distribution of antigenepithelial cells, fibroblasts, leukocytes
Entrez Gene ID3675
RRIDAB_2751538, AB_2658479, AB_2658480, AB_2658483, AB_2658484, AB_2658485, AB_2658486, AB_2658487, AB_2658488, AB_2658489, AB_2658490, AB_2658491, AB_2658492, AB_2658493, AB_2658494, AB_2751548

Resources for CD49c Antibody, anti-human, REAfinity™

Certificates

Please follow this
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to search for Certificates of Analysis (CoA) by lot number.

References for CD49c Antibody, anti-human, REAfinity™

Publications

  1. Carter, W. G. et al. (1991) Epiligrin, a new cell adhesion ligand for integrin alpha 3 beta 1 in epithelial basement membranes. Cell 65(4): 599-610
  2. Takada, Y. et al. (1991) Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen. J. Cell Biol. 115(1): 257-266
  3. de Melker, A. A. et al. (1997) The A and B variants of the alpha 3 integrin subunit: tissue distribution and functional characterization. Lab. Invest. 76(4): 547-563

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