Clone:
DCN228
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1κ
Applications:
FC, MICS, IF, IHC
Alternative names:
MRC1, CLEC13D, CLEC13DL, MMR, MRC1L1

Specifications for CD206 Antibody, anti-human

Overview

The mannose receptor (MR), also known as macrophage MR or CD206, is a 162–175 kDa type I membrane protein. It contains an N-terminal cystein-rich domain and eight C-type lectin-like domains (CTLDs), beside a transmembrane and a cytoplasmic domain. CD206 is expressed by macrophages, dendritic cells, and subsets of endothelial cells, but not on monocytes. The MR recognizes multiple mainly microbial carbohydrates with mannose, fucose, or N-acetyl glucosamine residues. The MR mediates endocytosis and phagocytosis, linked to antigen presentation. It plays an important role in host defense and provides a link between innate and adaptive immunity.

Alternative names

MRC1, CLEC13D, CLEC13DL, MMR, MRC1L1

Detailed product information

Technical specifications

CloneDCN228
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
AntigenCD206
Alternative names of antigenMRC1, CLEC13D, CLEC13DL, MMR, MRC1L1
Molecular mass of antigen [kDa]164
Distribution of antigendendritic cells, endothelial cells, macrophages, plasma cells, placenta
Entrez Gene ID4360
RRIDAB_2819507, AB_2876900, AB_2876901, AB_2661049, AB_2661050, AB_2661051, AB_2661052, AB_2661053, AB_2661054, AB_10827698, AB_2819542

Resources for CD206 Antibody, anti-human

Certificates

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References for CD206 Antibody, anti-human

Publications

  1. Tacken, P. J. et al. (2005) Effective induction of naive and recall T-cell responses by targeting antigen to human dendritic cells via a humanized anti-DC-SIGN antibody. Blood 106: 1278-1285
  2. Ezekowitz, R. A. B. et al. (1990) Molecular characterization of the human macrophage mannose receptor: demonstration of multiple carbohydrate recognition-like domains and phagocytosis of yeasts in Cos-1 cells. J. Exp. Med. 172: 1785-1794
  3. Kang, P. B. et al. (2005) The human macrophage mannose receptor directs Mycobacterium tuberculosis lipoarabinomannan-mediated phagosome biogenesis. J. Exp. Med. 202: 987-999
  4. Sallusto, F. et al. (1995) Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartement: downregulation by cytokines and bacterial products.​ J. Exp. Med. 182: 389-400
  5. Wileman, T. E. et al. (1986) Identification of the macrophage mannose receptor as a 175-kDa membrane protein. Proc. Natl. Acad. Sci. U.S.A. 83: 2501-2505
  6. Feinberg, H. et al. (2000) Structure of a C-type carbohydrate recognition domain from the macrophage mannose receptor. J. Biol. Chem. 275: 21539-21548
  7. Lennartz, M. R. et al. (1989) Biosynthesis and processing of the mannose receptor in human macrophages. J. Biol. Chem. 264: 2385-2390
  8. Yee Seng Ng (2012) Chemical transfection of dye-conjugated microRNA precursors for microRNA functional analysis of M2 macrophages. J. Cell. Biochem. 113(5): 1714-1723

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