Clone:
MR1
Type of antibody:
Primary antibodies
Isotype:
hamster IgG3κ
Applications:
FC, ICFC
Alternative names:
CD40LG, CD40L, HIGM1, IGM, IMD3, Ly-62, T-BAM, TRAP, TNFSF5, gp39

Specifications for CD154 Antibody, anti-mouse

Overview

Clone MR1 specifically recognizes the mouse CD154 antigen, a 39 kDa transmembrane glycoprotein also known as CD40L, gp39, T-BAM, TRAP, or Ly-62. CD154 is transiently up-regulated on activated CD4
+
T cells and plays an important role as a costimulatory molecule in T cell/antigen-presenting cell interactions through ligation of CD40. The antibody has been shown to block the activation of antigen-presenting cells by T helper cells
in vitro
. Due to its transient expression within hours after activation, CD154 can be used as a marker for activated antigen-specific CD4
+
T cells. Adding a CD40-blocking antibody during the stimulation of cell suspensions prevents the down-regulation of CD154. Blocking of CD40 is not required for intracellular detection of CD154 expression or if a pure population of enriched T cells is used.

Alternative names

CD40LG, CD40L, HIGM1, IGM, IMD3, Ly-62, T-BAM, TRAP, TNFSF5, gp39

Detailed product information

Technical specifications

CloneMR1
Clonalitymonoclonal
Isotypehamster IgG3κ
Hosthamster
Type of antibodyPrimary antibodies
Speciesmouse
AntigenCD154
Alternative names of antigenCD40LG, CD40L, HIGM1, IGM, IMD3, Ly-62, T-BAM, TRAP, TNFSF5, gp39
Molecular mass of antigen [kDa]29
Distribution of antigendendritic cells, macrophages, mast cells, monocytes, NK cells, T cells, lymphocytes, basophils
Entrez Gene ID21947
RRIDAB_2661125, AB_2661126, AB_2661127, AB_2661128, AB_2661124

Resources for CD154 Antibody, anti-mouse

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

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CD154 Antibody, anti-mouse

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