Clone:
REA400
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, MICS, IF, IHC
Alternative names:
TNNT2, CMD1D, CMH2, CMPD2, LVNC6, RCM3, TnTc, cTnT

Specifications for Cardiac Troponin T Antibody, anti-human/mouse/rat, REAfinity™

Overview

Clone REA400 recognizes the human, mouse, and rat cardiac troponin T antigen, a protein which is exclusively expressed at high concentrations in cardiac muscle and has emerged as the preferred biomarker in the universal definition of myocardial infarction. Cardiac troponin T is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in the cardiac troponin T gene have been associated with familial hypertrophic cardiomyopathy as well as with restrictive and dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms. Mutations of this gene may be associated with mild or absent hypertrophy and predominant restrictive disease, with a high risk of sudden cardiac death. Pluripotent stem cells (PSCs) differentiate into cardiomyocytes positive for cardiac troponin T and showing spontaneous rhythmic contractions. Therefore, PSC-derived cardiomyocytes have emerged as a potential source for cardiac regeneration after myocardial infarction.
Additional information: Clone REA400 displays negligible binding to Fc receptors.

Alternative names

TNNT2, CMD1D, CMH2, CMPD2, LVNC6, RCM3, TnTc, cTnT

Detailed product information

Technical specifications

CloneREA400
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse, rat
AntigenCardiac Troponin T
Alternative names of antigenTNNT2, CMD1D, CMH2, CMPD2, LVNC6, RCM3, TnTc, cTnT
Molecular mass of antigen [kDa]36(refers to canonical form)
Distribution of antigenother, cardiac muscle
Entrez Gene ID7139, 21956, 24837
RRIDAB_2751735, AB_2801770, AB_2801761, AB_2783888, AB_2783887, AB_2783892, AB_2783891, AB_2783890, AB_2783889, AB_2651340, AB_2751795

Resources for Cardiac Troponin T Antibody, anti-human/mouse/rat, REAfinity™

Certificates

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References for Cardiac Troponin T Antibody, anti-human/mouse/rat, REAfinity™

Publications

  1. Mesnard, L. et al. (1993) Molecular cloning and developmental expression of human cardiac troponin T. FEBS Lett. 328(1-2): 139-144
  2. Yu, S. et al. (2014) Differentiation of human embryonic germ cells and transplantation in rats with acute myocardial infarction. Exp Ther Med. 7(3): 615-620
  3. Arshi, A. et al. (2013) Rigid microenvironments promote cardiac differentiation of mouse and human embryonic stem cells. Sci. Technol. Adv. Mater. 14(2): pii: 025003

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