Clone:
REA134
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
AKT, CWS6, PKB, PRKBA, RAC, RAC-ALPHA, PKBα

Specifications for AKT1 Antibody, anti-human, REAfinity™

Overview

Clone REA134 recognizes AKT1, which is also known as protein kinase Bα. AKT1 is a serine/threonine protein kinase, belonging to the AKT family of kinases and like each AKT family member, contains an N-terminal pleckstrin homology (PH) domain, a central kinase domain, and a carboxyl-terminal regulatory domain with a hydrophobic motif (HM). Activation of AKT1 is achieved via phosphorylation at multiple sites, which take place in response to engagement of receptors such as platelet derived growth factor receptor (PDGF-R). Activated AKT1 further phosphorylates and alters the activity of several downstream substrates allowing AKT1 to play a vital role in various biological processes such as cell growth, survival, migration, and proliferation.
Additional information: Clone REA134 displays negligible binding to Fc receptors.

Alternative names

AKT, CWS6, PKB, PRKBA, RAC, RAC-ALPHA, PKBα

Detailed product information

Technical specifications

CloneREA134
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenAKT1
Alternative names of antigenAKT, CWS6, PKB, PRKBA, RAC, RAC-ALPHA, PKBα
RRIDAB_2651218, AB_2651219, AB_2651220, AB_2651221, AB_2651222, AB_2651223, AB_2651224, AB_2651217

Resources for AKT1 Antibody, anti-human, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for AKT1 Antibody, anti-human, REAfinity™

Publications

  1. Calamito, M. et al. (2010) Akt1 and Akt2 promote peripheral B-cell maturation and survival. Blood 115: 4043-4050
  2. Arranz, A. et al. (2012) Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization. Proc. Natl. Acad. Sci. U.S.A. 109(24): 9517-9522

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AKT1 Antibody, anti-human, REAfinity™

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