UltraMicroscope Blaze™

Automated light sheet imaging of large samples

The UltraMicroscope Blaze is the only fully automated light sheet microscope for imaging large or multiple cleared samples. It covers the range from analyzing entire mice to multiple organs and organoids with subcellular resolution. The combination of our pioneering UltraMicroscope technology with cutting-edge light sheet optics ensures excellent data quality. 

The UltraMicroscope Blaze received the Wiley Analytical Science Award 2021 in the category "Spectroscopy and Microscopy" less than a year after the instrument's introduction to the market. A huge thank you to all our customers who voted and secured us this success. 
 

Benefits

Full automation

The UltraMicroscope Blaze enables an automated sample release and smooth switching between different objectives and magnification lenses, while keeping images sharp with the autofocus feature. 

Large sample chamber  

Benefit from the large sample chamber that can contain a whole cleared mouse model or multiple samples at once, which can then  be imaged sequentially together.

Easy adaptation 

Whether imaging large organs or even entire mouse models, our wide range of dipping caps guarantees high image quality in all clearing media - from water to organic solvents.

High-resolution 

The combination of the MI Plan objective lenses and the cutting-edge light sheet illumination technology ensures unprecedented image quality from overview to sub-cellular details.

 

Features and specifications 

UltraMicroscope UM Blaze

MI Plan objectives

MI Plan objectives (1.1×, 4×, and 12×) are optimized for high-resolution 3D imaging of large samples in any clearing media.

Large automated chamber

Image a whole cleared mouse or multiple organs without user intervention and exchange samples easily by automated sample release.

Automated detection unit

Fully automated switching of all lenses combined with the autofocus feature ensure a convenient imaging process.

Cutting-edge light sheet optics

Up to six light sheets make for improved optical sectioning and homogeneous illumination.

1 2 3 4

MI Plan objectives

MI Plan objectives (1.1×, 4×, and 12×) are optimized for high-resolution 3D imaging of large samples in any clearing media.

Large automated
chamber

Image a whole cleared mouse or multiple organs without user intervention and exchange samples easily by automated sample release.

Automated detection unit

Fully automated switching of all lenses combined with the autofocus feature ensure a convenient imaging process.

Cutting-edge light sheet optics

Up to six light sheets make for improved optical sectioning and homogeneous illumination.

UltraMicroscope UM Blaze
  • Gregorius, J. et al. (2021) Small extracellular vesicles obtained from hypoxic mesenchymal stromal cells have unique characteristics that promote cerebral angiogenesis, brain remodeling and neurological recovery after focal cerebral ischemia in mice Basic Res Cardiol 116(1): 40
  • Michel, L. et al. (2021) Targeting early stages of cardiotoxicity from anti-PD1 immune checkpoint inhibitor therapy Eur Heart J.
  • Taranda, J. et al. (2021) 3D Whole-Brain Imaging Approaches to Study Brain Tumors Cancers (Basel) 13(8): 1897
  • Vigouroux, R. J. et al. (2021) Bilateral visual projections exist in non-teleost bony fish and predate the emergence of tetrapods Science 372(6538): 150-156
  • Zhao, S. et al. (2020) Tridimensional Visualization and Analysis of Early Human Development. Cell 180(4): 796-812
  • Pan, C. et al. (2019) Deep Learning Reveals Cancer Metastasis and Therapeutic Antibody Targeting in the Entire Body. Cell 179(7): 1661-1676
 

Applications

The UltraMicroscope Blaze allows us to see every single cancer metastasis in the whole bodies of transparent mice and we can also see if drugs are targeting all those tiny micro-metastases. The UltraMicroscope Blaze will be a powerful tool for drug development in oncology. 
Dr. Ali Ertürk
Director of iTERM, Helmholtz Zentrum München, Germany
 

Support

Service where you need it

 

UltraMicroscope Blaze

Automated light sheet imaging of largest samples

Order no. 150-001-760

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