Clone:
188B
Type of antibody:
Primary antibodies
Isotype:
mouse IgG2aκ
Applications:
FC, MICS, IF, IHC
Alternative names:
CCK-4, CCK4

Specifications for PTK7 (CCK-4) Antibody, anti-human

Overview

The Anti-PTK7 (CCK-4) antibody (clone 188B) recognizes human protein tyrosine kinase-7 (PTK7). PTK7, also known as colon carcinoma kinase-4 (CCK-4), is a receptor protein tyrosine kinase (RPTK)–like molecule that contains a catalytically inactive tyrosine kinase domain. PTK7 was identified to be important for neural development as a regulator of planar cell polarity, being required for convergent extension movement and neural tube closure. Using the Anti-PTK7 (CCK-4) antibody, PTK7 expression was recently analyzed on blood and bone marrow cells. PTK7 was shown to be expressed on plasmacytoid dendritic cells, CD141 (BDCA-3)
high
type-2 myeloid dendritic cells, and CD34
+
hematopoietic progenitor cells (HPCs). PTK7 was detected on early (CD34
+
CD133
+
) and late (CD34
+
CD133
) HPCs. In tonsils, PTK7 was also found on some T cells.

Alternative names

CCK-4, CCK4

Detailed product information

Technical specifications

Clone188B
Clonalitymonoclonal
Isotypemouse IgG2aκ
Isotype controlIsotype Control Antibody, mouse IgG2a
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
AntigenPTK7 (CCK-4)
Alternative names of antigenCCK-4, CCK4
Molecular mass of antigen [kDa]115
Entrez Gene ID5754
RRIDAB_2801970, AB_2661302, AB_2661303, AB_2661305, AB_615145, AB_2661306, AB_615146, AB_615144, AB_2801991

Resources for PTK7 (CCK-4) Antibody, anti-human

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for PTK7 (CCK-4) Antibody, anti-human

Publications

  1. Lu, X. et al. (2004) PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates. Nature 430: 93-98
  2. Park, S. K. et al. (1996) Characterization of the human full-length PTK7 cDNA encoding a receptor protein tyrosine kinase-like molecule closely related to chick KLG. J. Biochem. 119(2): 235-239
  3. Mossie, K. et al. (1995) Colon carcinoma kinase-4 defines a new subclass of the receptor tyrosine kinase family. Oncogene 11: 2179-2184
  4. Xiao, Z. et al. (2008) Cell-specific internalization study of an aptamer from whole cell selection. Chemistry 14: 1769-1775
  5. Katoh, M. and Katoh, M. (2007) Comparative integromics on non-canonical WNT or planar cell polarity signaling molecules: transcriptional mechanism of PTK7 in colorectal cancer and that of SEMA6A in undifferentiated ES cells. Int. J. Mol. Med. 20: 405-409

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