Pan DC MicroBeads consist of CD11c and Anti-mPDCA-1 MicroBeads. The combination of both, the CD11c and Anti-mPDCA-1 MicroBeads, together ensures the highest recovery and purity of all DCs in one isolation step.

Data and images for Pan DC MicroBeads, mouse

Figures

Figure 1

Spleen cells before separation
Spleen cells depleted of DCs
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Figure 1

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Figure 1

Isolated total DCs
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Figure 1

Specifications for Pan DC MicroBeads, mouse

Overview

Pan DC MicroBeads consist of CD11c and Anti-mPDCA-1 MicroBeads. The combination of both, the CD11c and Anti-mPDCA-1 MicroBeads, together ensures the highest recovery and purity of all DCs in one isolation step.

Detailed product information

Background information

While CD11c is expressed at high levels on classical dendritic cells (DCs), it is only expressed at low to intermediate levels on plasmacytoid dendritic cells (PDCs).
The mouse plasmacytoid dendritic cell antigen-1 (mPDCA-1) is specifically expressed on PDCs with the phenotype CD11c
low
, CD45R(B220)
+
, and Ly-6C
+
in lymphoid and non-lymphoid tissues. Due to the low expression of CD11c on PDCs, using CD11c expression alone might not lead to enrichment of PDCs to the same extent as classical DCs.

Downstream applications

Mouse DCs isolated with Pan DC MicroBeads are suitable for phenotypical and functional analyses, molecular analyses, coculture experiments to evaluate their interaction with other cell types, migration experiments, or adoptive transfer.

Columns

For positive selection: MS, LS, XS, or autoMACS
®
Columns. For depletion: LD, D, or autoMACS Columns.

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