Clone:
REA660
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, MICS
Alternative names:
CTLA-8, IL-17

Specifications for IL-17A Antibody, anti-mouse, REAfinity™

Overview

Clone REA660 recognizes mouse interleukin 17A (IL-17A). Interleukin 17 (IL-17) is a family of cytokines that play a central role in adaptive immunity as well as autoinflammatory disorders. Data from several mouse models suggest that IL-17 plays a key role in the host defense against certain extracellular bacterial infections.
Recently, a new mouse T helper cell subset has been identified, which is dinstinct from Tʜ1 and Tʜ2 cells: IL-17–producing CD4
+
T helper (Tʜ17) cells. Tʜ17 cells preferentially produce IL-17A, IL-17F, IL-21, and IL-22. Receptors for IL-17 and IL-22 are expressed on various epithelial tissues, thus Tʜ17 cells are crucial for the cross-talk between immune system and tissues. It is now established that Tʜ17 cells are responsible for driving autoimmune inflammation. After stimulation of mouse T cells, IL-17 is not only secreted by CD4
+
T cells, but also by CD8
+
T cells and γδ T cells.
Additional information: Clone REA660 displays negligible binding to Fc receptors.

Alternative names

CTLA-8, IL-17

Detailed product information

Technical specifications

CloneREA660
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenIL-17A
Alternative names of antigenCTLA-8, IL-17
Molecular mass of antigen [kDa]15
Distribution of antigenepithelial cells
Entrez Gene ID16171
RRIDAB_2652359, AB_2652360, AB_2652361, AB_2652362, AB_2652363, AB_2652358

Resources for IL-17A Antibody, anti-mouse, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for IL-17A Antibody, anti-mouse, REAfinity™

Publications

  1. Zheng, S. et al. (2017) Human gingiva-derived mesenchymal stem cells ameliorate Streptozoticin-induced T1DM in mice via suppression of T effector cells and up-regulating Treg subsets. Sci Rep 7(1): 15249
  2. Kennedy, J. et al. (1996)
    Mouse IL-17: a cytokine preferentially expressed by alpha beta TCR + CD4
    CD8
    T cells.
    J. Interferon Cytokine Res. 16(8): 611-617
  3. Weaver, C. T. et al. (2007) IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu. Rev. Immunol. 25: 821-852
  4. Ouyang, W. et al. (2008) The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity 28: 454-467

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