Clone:
REA858
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, IF, IHC
Alternative names:
proliferating-cell-nuclear-antigen, Cyclin

Specifications for PCNA Antibody, anti-human/mouse/rat, REAfinity™

Overview

Clone REA858 recognizes the human, mouse, and rat proliferating cell nuclear antigen (PCNA), a 36 kDa nuclear protein also known as cyclin or auxiliary protein of DNA polymerase delta. PCNA is expressed in the nucleus of all proliferating cells. PCNA plays a role in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Furthermore, it is involved in DNA damage response by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways.
Additional information: Clone REA858 displays negligible binding to Fc receptors.

Alternative names

proliferating-cell-nuclear-antigen, Cyclin

Detailed product information

Technical specifications

Clone
REA858
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse, rat, non-human primate, other
Cross-reactivity
cynomolgus monkey (
Macaca fascicularis
)
,
rhesus monkey (
Macaca mulatta
)
, chicken, rabbit, hamster, horse, sheep, dog, cat, ferret, xenopus
AntigenPCNA
Alternative names of antigenproliferating-cell-nuclear-antigen, Cyclin
Molecular mass of antigen [kDa]29(same molecular weight for human and mouse/rat)
Entrez Gene ID5111, 18538, 25737
RRIDAB_2726679, AB_2726764, AB_2726680, AB_2726765, AB_2726681, AB_2726766, AB_2726682, AB_2726763

References for PCNA Antibody, anti-human/mouse/rat, REAfinity™

Publications

  1. Landberg, G. et al. (1990) Flow cytometric multiparameter analysis of proliferating cell nuclear antigen/cyclin and Ki-67 antigen: a new view of the cell cycle. Exp. Cell Res. 187(1): 111-118
  2. Guzińska-Ustymowicz, K. et al. (2009) Correlation between proliferation markers: PCNA, Ki-67, MCM-2 and antiapoptotic protein Bcl-2 in colorectal cancer. Anticancer Res. 29(8): 3049-3052
  3. Cazzalini, O. et al. (2014) CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis. Nucleic Acids Res. 42(13): 8433-8448
  4. Ortega, J. et al. (2015) Phosphorylation of PCNA by EGFR inhibits mismatch repair and promotes misincorporation during DNA synthesis. Proc. Natl. Acad. Sci. U.S.A. 112(18): 5667-5672

Related products for
PCNA Antibody, anti-human/mouse/rat, REAfinity™

4 products available