Clone:
REA1098
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
LFA-3, ag3

Specifications for CD58 (LFA-3) Antibody, anti-human, REAfinity™

Overview

Clone REA1098 recognizes human CD58, a 45–70 kDa cell surface molecule which is a member of the immunoglobin superfamily. It is expressed on professional APCs (antigen-presenting cells) such as B cells, dendritic cells, macrophages, and epithelial cells as well as on T cells, monocytes, erythrocytes, endothelial cells, and fibroblasts. LFA-3 interacts with CD2 on T cells and is important for interaction between T cells and professional APCs.
Additional information: Clone REA1098 displays negligible binding to Fc receptors.

Alternative names

LFA-3, ag3

Detailed product information

Technical specifications

CloneREA1098
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD58 (LFA-3)
Alternative names of antigenLFA-3, ag3
Molecular mass of antigen [kDa]25
Distribution of antigenantigen-presenting cells, B cells, dendritic cells, endothelial cells, epithelial cells, fibroblasts, macrophages, monocytes, T cells, red blood cells
Entrez Gene ID965
RRIDAB_2733734, AB_2733735, AB_2733314, AB_2733315, AB_2732940, AB_2732941, AB_2733990, AB_2733991

References for CD58 (LFA-3) Antibody, anti-human, REAfinity™

Publications

  1. Sanchez-Madrid, F. et al. (1982) Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3. Proc. Natl. Acad. Sci. U.S.A. 79: 7489-7493
  2. Dengler, T. J. et al. (1992) Structural and functional epitopes of the human adhesion receptor CD58 (LFA-3). Eur. J. Immunol. 22(11): 2809-2817
  3. Wang, J. H. et al. (1999) Structure of a heterophilic adhesion complex between the human CD2 and CD58 (LFA-3) counterreceptors. Cell 97(6): 791-803