StemMACS™ LDN-193189 is a selective and highly potent small molecule inhibitor of BMP signaling.

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Chemical structure of StemMACS™ LDN-193189
Chemical structure of StemMACS™ LDN-193189

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Overview

StemMACS™ LDN-193189 is a selective and highly potent small molecule inhibitor of BMP signaling.

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Background information

StemMACS™ LDN-193189 inhibits the BMP type I receptors ALK2 (IC50 = 5 nM) and ALK3 (IC50 = 30 nM) and prevents phosphorylation of their downstream targets Smad1, Smad5 and Smad8. In contrast, LDN-193189 has little effect on ALK4, ALK5, and ALK7. LDN-193189 is a derivative of dorsomorphin, and has been used instead of the protein Noggin for inhibition of BMP signaling. In pluripotent stem cell research, LDN-103189 is used together with small molecules or growth factors to modulate stem cell differentiation, e.g., during neural induction or dopaminergic differentiation.

Applications

Published applications of LDN-193189 include:
  • Differentiation of human ES and iPS cells into neural progenitors (in combination with SB431542)1
  • Differentiation of human ES and iPS cells into neural crest cells2

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References for StemMACS™ LDN-193189

Publications

  1. Chambers, S.M. et al. (2012) Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors. Nat. Biotechnol. 30(7): 715-720
  2. Kreitzer, FR et al. (2013) A robust method to derive functional neural crest cells from human pluripotent stem cells. Am J Stem Cells 2(2): 119-131

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