Clone:
REA549
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, MICS, IF, IHC
Alternative names:
MGF, STAT5

Specifications for STAT5a Antibody, anti-human, REAfinity™

Overview

Clone REA549 recognizes the human STAT5a antigen, a member of signal transducers and activators of the transcription (STAT) family. The seven STAT family members play a critical role in activation of signaling pathways in response to the presence of various cytokines and growth factors (interferon (IFN)-α, IFN-γ, EGF, PDGF, and interleukin (IL)-6). STAT5a regulates the expression of milk proteins during lactation and mediates cellular responses to the receptor tyrosine-protein kinase ERBB4. It may induce cellular responses to activated FGFR1, FGFR2, FGFR3, and FGFR4. Among others STAT5a is expressed in prostate and breast cancer.
Additional information: Clone REA549 displays negligible binding to Fc receptors.

Alternative names

MGF, STAT5

Detailed product information

Technical specifications

CloneREA549
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenSTAT5a
Alternative names of antigenMGF, STAT5
Molecular mass of antigen [kDa]91
Entrez Gene ID6776
RRIDAB_2653582, AB_2653583

Resources for STAT5a Antibody, anti-human, REAfinity™

Certificates

Please follow this
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to search for Certificates of Analysis (CoA) by lot number.

References for STAT5a Antibody, anti-human, REAfinity™

Publications

  1. Williams, C. C. et al. (2004) The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone. J. Cell Biol. 167(3): 469-478
  2. Lin, J. X. et al. (2000) The role of Stat5a and Stat5b in signaling by IL-2 family cytokines. Oncogene 19(21): 2566-2576
  3. Aoki, N. et al. (2002) A nuclear protein tyrosine phosphatase TC-PTP is a potential negative regulator of the PRL-mediated signaling pathway: dephosphorylation and deactivation of signal transducer and activator of transcription 5a and 5b by TC-PTP in nucleus. Mol Endocrinol. 16(1): 58-69

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