Clone:
REA324
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, MICS, IF, IHC
Alternative names:
ADMIO, APRF, HIES

Specifications for STAT3 pS727 Antibody, anti-human, REAfinity™

Overview

Clone REA324 recognizes the signal transducer and activator of transcription 3 (STAT3) antigen phosphorylated at serine 727 (pS727). STAT3 expression is found ubiquitously. It is activated in response to various growth factors, hormones, and cytokines, and has an important role in their signaling. When these ligands bind to the specific transmembrane STAT3 receptor, STAT3 becomes activated by tyrosine phosphorylation of two important phosphorylation sites, pY705 and pS727. The dimeric STAT3 translocates to the nucleus, where it binds to consensus STAT3 binding sequences within the promoter region of target genes and thereby activates their transcription. The persistent activation of STAT3 also mediates tumor-promoting inflammation. STAT3 promotes pro-oncogenic inflammatory pathways in tumor inflammation and immunity, including nuclear factor-κB and interleukin-6-GP130-Janus kinase pathways, and by opposing STAT1- and NF-κB-mediated T helper 1 anti-tumor immune responses.
Additional information: Clone REA324 displays negligible binding to Fc receptors.

Alternative names

ADMIO, APRF, HIES

Detailed product information

Technical specifications

CloneREA324
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenSTAT3 pS727
Alternative names of antigenADMIO, APRF, HIES
Molecular mass of antigen [kDa]88
Distribution of antigenother
Entrez Gene ID6774
RRIDAB_2811548, AB_2653578, AB_2653579, AB_2811579

Resources for STAT3 pS727 Antibody, anti-human, REAfinity™

Certificates

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References for STAT3 pS727 Antibody, anti-human, REAfinity™

Publications

  1. Zhang, X. et al. (1995) Requirement of serine phosphorylation for formation of STAT-promoter complexes Science 267(5206): 1990-1994
  2. Sakaguchi, M. et al. (2012) Role and regulation of STAT3 phosphorylation at Ser727 in melanocytes and melanoma cells J. Invest. Dermatol. 132(7): 1877-1885
  3. Yu, H. et al. (2009) STATs in cancer inflammation and immunity: a leading role for STAT3 Nat. Rev. Cancer 9(11): 798-809

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