Clone:
REA434
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
ASV, SRC1, c-Src, p60-Src, pp60c-src

Specifications for Src pY418 Antibody, anti-human, REAfinity™

Overview

Clone REA434 recognizes the human proto-oncogene tyrosine-protein kinase Src phosphorylated at tyrosine 418 (pY418). Src is a non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins, and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors, as well as cytokine receptors. It participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Src appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Src activity is regulated by phosphorylation at key sites, including the autophosphorylation site pY418 and the inhibitory site pY529.
Additional information: Clone REA434 displays negligible binding to Fc receptors.

Alternative names

ASV, SRC1, c-Src, p60-Src, pp60c-src

Detailed product information

Technical specifications

CloneREA434
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse, rat, other
Cross-reactivitymouse, rat, chicken
AntigenSrc pY418
Alternative names of antigenASV, SRC1, c-Src, p60-Src, pp60c-src
Molecular mass of antigen [kDa]60(refers to canonical form)
Distribution of antigenother
Entrez Gene ID6714
RRIDAB_2653506, AB_2653507, AB_2653508, AB_2653505

Resources for Src pY418 Antibody, anti-human, REAfinity™

Certificates

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References for Src pY418 Antibody, anti-human, REAfinity™

Publications

  1. Roskoski, R. (2005) Src kinase regulation by phosphorylation and dephosphorylation. Biochem. Biophys. Res. Commun. 331(1): 1-14
  2. Wu, S. S. et al. (2005) Bombesin and angiotensin II rapidly stimulate Src phosphorylation at Tyr-418 in fibroblasts and intestinal epithelial cells through a PP2-insensitive pathway. Cell. Signal. 17(1): 93-102
  3. Tanaka, A. et al. (1987) DNA sequence encoding the amino-terminal region of the human c-src protein: implications of sequence divergence among src-type kinase oncogenes. Mol. Cell. Biol. 7(5): 1978-1983

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