Clone:
REA488
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
PLCG2, APLAID, FCAS3, PLC-IV, PLC-gamma-2

Specifications for PLC-γ2 Antibody, anti-human, REAfinity™

Overview

Clone REA488 recognizes the human phosphoinositide phospholipase C-γ-2 (PLC-γ2) antigen regardless of phosphorylation status. PLC-γ isoforms are mainly regulated through receptors with intrinsic tyrosine kinase activity (e.g. growth factor receptors) or receptors (such as B and T cell–antigen receptors) that are linked to the activation of non-receptor tyrosine kinases through a complex signaling network. The two isoforms of PLC-γ have distinct tissue distributions. Whereas PLC-γ1 is expressed ubiquitously, the pattern of expression of PLC-γ2 is characterized by high levels in cells of hematopoietic origin. PLC-γ2 is a transmembrane signaling enzyme that catalyzes the conversion of phosphatidyl inositol biphosphate to inositol triphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. It has been implicated in collagen-induced signal transduction in platelets and antigen-dependent signaling in B lymphocytes. PLC-γ2 is regulated through activation of tyrosine kinase-linked receptors. Homozygous disruption of PLC-γ2 results in functional and signaling disorders in a subset of cell types including B cells, platelets, and mast cells.
Additional information: Clone REA488 displays negligible binding to Fc receptors.

Alternative names

PLCG2, APLAID, FCAS3, PLC-IV, PLC-gamma-2

Detailed product information

Technical specifications

CloneREA488
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse
Cross-reactivitymouse
AntigenPLC-γ2
Alternative names of antigenPLCG2, APLAID, FCAS3, PLC-IV, PLC-gamma-2
Molecular mass of antigen [kDa]148
Distribution of antigenB cells, leukocytes, macrophages, monocytes, lymphocytes, NK cells, mast cells, T cells, gastric carcinoma cells, T helper cells, NKT cells, basophils, eosinophils, neutrophils
Entrez Gene ID5336
RRIDAB_2653218, AB_2653219, AB_2653220, AB_2653221, AB_2653222, AB_2653217

Resources for PLC-γ2 Antibody, anti-human, REAfinity™

Certificates

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References for PLC-γ2 Antibody, anti-human, REAfinity™

Publications

  1. Hikida, M. et al. (2009) PLC-gamma2 is essential for formation and maintenance of memory B cells. J. Exp. Med. 206(3): 681-689
  2. Ohta, S. et al. (1988) Complete cDNA encoding a putative phospholipase C from transformed human lymphocytes. FEBS Lett. 242(1): 31-35
  3. Feng, L. et al. (2012) The effect of PLC-γ2 inhibitors on the growth of human tumour cells. Eur J Med Chem 54: 463-469

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