Clone:
REA821
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
PRKCA, AAG6, PKC-alpha, PRKACA, PKC-A

Specifications for PKCα pT497 Antibody, anti-human, REAfinity™

Overview

Clone REA821 recognizes the PKCα antigen phosphorylated at threonine 497. PKCα has been reported to crossreact with PKCβ. PKCα is a serine- and threonine-specific protein kinase that can be activated by calcium and the second messenger diacylglycerol. It plays roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. PKCα is highly expressed in a number of cancer cells where it can acts as a tumor promoter and it is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca
2+
handling in myocytes.
Additional information: Clone REA821 displays negligible binding to Fc receptors.

Alternative names

PRKCA, AAG6, PKC-alpha, PRKACA, PKC-A

Detailed product information

Technical specifications

CloneREA821
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenPKCα pT497
Alternative names of antigenPRKCA, AAG6, PKC-alpha, PRKACA, PKC-A
Molecular mass of antigen [kDa]77
Distribution of antigentumor cells, breast cancer cells
Entrez Gene ID5578
RRIDAB_2725841, AB_2725860, AB_2725842, AB_2725861, AB_2725843, AB_2725859

Resources for PKCα pT497 Antibody, anti-human, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for PKCα pT497 Antibody, anti-human, REAfinity™

Publications

  1. Finkenzeller, G. et al. (1990) Sequence of human protein kinase C alpha. Nucleic Acids Res. 18(8): 2183
  2. Xu, H. et al. (2008) Protein kinase C alpha promotes angiogenic activity of human endothelial cells via induction of vascular endothelial growth factor. Cardiovasc. Res. 78(2): 349-355

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