Clone:
REA507
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
AN, Oculorhombin, D11S812E, FVH1, MGDA, WAGR, AN2

Specifications for PAX-6 Antibody, anti-human, REAfinity™

Overview

Clone REA507 recognizes the human paired box protein PAX-6 antigen, a member of the paired box (PAX) gene family whose protein products are transcription factors involved in development. During organogenesis, PAX-6 is required for establishment of various progenitor subtypes within the central nervous system, eye, and pancreas. PAX-6 expression is maintained in a variety of cell types within each organ. PAX-6 is abundantly expressed during patterning of the optic vesicles and during specification and differentiation of the retinal pigmented epithelium. Defects in PAX-6 are responsible for various eye malformations including aniridia and Peters' anomaly.
Additional information: Clone REA507 displays negligible binding to Fc receptors.

Alternative names

AN, Oculorhombin, D11S812E, FVH1, MGDA, WAGR, AN2

Detailed product information

Technical specifications

CloneREA507
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenPAX-6
Alternative names of antigenAN, Oculorhombin, D11S812E, FVH1, MGDA, WAGR, AN2
Molecular mass of antigen [kDa]47
Distribution of antigenother
Entrez Gene ID5080
RRIDAB_2819462, AB_2819471, AB_2819456, AB_2653170, AB_2819477

Resources for PAX-6 Antibody, anti-human, REAfinity™

Certificates

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References for PAX-6 Antibody, anti-human, REAfinity™

Publications

  1. Ouyang, H. et al. (2014) WNT7A and PAX6 define corneal epithelium homeostasis and pathogenesis. Nature 511(7509): 358-361
  2. Ton, C. C. et al. (1991) Positional cloning and characterization of a paired box- and homeobox-containing gene from the aniridia region. Cell 67(6): 1059-1074
  3. Klimova, L. et al. (2014) Stage-dependent requirement of neuroretinal Pax6 for lens and retina development. Development 141(6): 1292-1302

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